Apolipoprotein E (apo E) is a structural constituent of several serum lipoprotein classes. It plays an important role in lipid metabolism by acting as a ligand for low-density lipoprotein (LDL) and chylomicron remnant receptors. Three common alleles called e2, e3 and e4 have been described, which code for three protein isoforms (E2, E3 and E4). The polymorphism is clinically significant, and it...

The Supreme Court recently denied certiorari to review the Federal Circuit’s ruling in Apotex v. Pfizer (S. Ct. 906-1006, October 16, 2006). The ruling was predictable. Pfizer had mooted the case by providing a covenant not to sue Apotex on its Quinapril patent. But the underlying legal issue – subject matter jurisdiction in declaratory judgment cases – is currently pending before the Supreme C...

  Background :Some results exist on fetuin-A as marker for vascular disease in type 2diabetes. We examined the relationship between serum fetuin-A with some factors, in patients with type 2 diabetes mellitus (T2DM).   Methods : From October 2012 to June 2013, a total of 131 T2DM patients were recruited and evaluated for various parameters including HOMA-IR, Apo-A1, Apo-B100, body fat percentage...

the peroxisome proliferator-activated receptors (ppars) -α, -δ/β and -γ are the ligand-activated transcription factors involved in the regulation of fatty acid and lipoprotein metabolism, energy balance, cell proliferation and differentiation and atherosclerosis, etc. we investigated the associations of 10 single-nucleotide polymorphisms (snps) in ppars with apolipoprotein (apo) a-i/apob ratio ...

APO-B merupakan apolipoprotein terbesar dari fraksi Very Low Density Lipoprotein (VLDL). Hipertrigliseridemia membuat hati memproduksi lebih banyak VLDL dan LDL kaya trigliserida yang akan dihidrolisis untuk menghasilkan padat kecil (sd-LDL) melalui Cholesterol ester transfer protein (CETP) lipase hati. Sekitar 90% adalah LDL, rasio K-LDL/APO-B sebagai indikator partikel LDL. Penelitian ini dil...