background and objectives cannabinoids which are active compounds of marijuana show some pharmacological effects similar to the opioids. there are also functional interactions between both cannabinoid and opioid systems. in this study we investigated the role of cannabinoid receptors in central amygdala and its interaction with opioid system.   methods in the present study, we investigated the ...

OBJECTIVE Nano components are today's new wonder material. However, the safety or toxicity of these components in humans is not yet clear. In a previous study we indicated that nano ZnO (nZnO) has a stronger anxiolytic effect compared to the conventional ZnO (cZnO). The present study was designed to evaluate the intraperitoneal administration of an opioidergic receptor agonist and antagonist of...

The purpose of this longitudinal study (N = 2,745) was to determine whether adolescents' recent medical use of anxiolytic or sleep medication was associated with increased incidence of using someone else's prescription for these classes of medication (nonmedical use). Data were collected from adolescents attending 5 Detroit area secondary schools between December and April in 3 consecutive acad...

OBJECTIVE To examine the prescription rates in cancer patients of three common psychotropic drugs: anxiolytic/ hypnotic, antidepressant and antipsychotic. MATERIALS AND METHODS In this retrospective cohort study, data were extracted from the pharmacy database of University Malaya Medical Center (UMMC) responsible for dispensing records of patients stored in the pharmacy's Medication Managemen...

The present work is to evaluate the anxiolytic activity of a hydroalcoholic extract of Tephrosia purpuria (L) Pers (HAETP) in mice using the elevated plus-maze (EPM), elevated zero-maze (EZM), Y-maze and hole-board models. Furthermore, the anxiolytic effects of HAETP were compared to a known active anxiolytic drug diazepam. The extract, administered orally, in two different doses of HAETP 200 m...

The present study was undertaken to evaluate the anxiolytic activity of methanolic extract of Sapindus mukorossi Gaertn.(Sapindaceae). The anxiolytic activity was evaluated by Elevated plus maze, Y-maze, Hole-board, Actophotometer, and Marble-burying behavior models. The efficacy of the extract (200 and 400 mg/kg) was compared with the standard anxiolytic drugs Diazepam (2 mg/kg) and Fluoxetine...

In ancient to modern system of medicine Curculigo species has been recommended for relief of different central nervous system disorders. Under this reserach study the hexane, dichloromethane, ethyl acetate, methanolic and water extracts of Curculigo orchioides root were evaluated for anxiolytic activity using Elevated Plus Maze model (EPM) and Light Dark model (LDM) in mice. The methanolic and ...

The study attempts to evaluate whether neuropeptide Y (NPY) and corticotropin-releasing factor (CRF) are involved in anxiogenic and anxiolytic reactions induced by NMDA receptor ligands. The animals were given MK-801 (1 mg/kg, ip), a non-competitive NMDA-receptor antagonist, which acts as anxiolytic agent, or NMDA (15 mg/kg, ip), which has an anxiogenic effect. The anxiogenic or anxiolytic acti...

Introduction: The mechanisms of hepatic encephalopathy are not fully understood. Moreover, there is no comprehensive data concerning the effects of nitric oxide (NO) system on anxiolytic-like behaviors induced by bile duct ligation (BDL). Methods: Male mice weighing 25-30 g were used and anxiety-like behaviors were tested using hole-board task. Results: The data indicated that cholestasis incre...

The present study was designed to evaluate the effects of bulbectomy and acute administration of anxiolytic drugs (diazepam, 10 mg/kg; chlordiazepoxide, 10 mg/kg) on the behavior of both sham-operated and olfactory bulbectomized rats in two tests predictive of anxiolytic activity: plus-maze test and Vogel's conflict test. We investigated also the effect of flumazenil (10 mg/kg), a benzodiazepin...