Many children who undergo surgery experience significant perioperative anxiety. Preoperative anxiety can prolong induction of anesthesia and postoperative recovery, increase the risk of postoperative delirium, increase pain, and increase analgesic use. Researchers are looking for ways to treat or prevent preoperative anxiety in children and possibly reduce its negative effects after surgery, su...

BACKGROUND Studies conducted in adults undergoing surgery reported a beneficial effect of oral melatonin administered before surgery. There is a paucity of such data in children undergoing anesthesia and surgery. METHODS Children undergoing surgery were randomly assigned to receive preoperatively oral midazolam 0.5 mg/kg or oral melatonin 0.05 mg/kg, 0.2 mg/kg, or 0.4 mg/kg. The primary outco...

oxidative stress (os), which has been implicated in pathogenesis of many acute and chronic diseases, plays an important role in diverse neurological disorders including depression and anxiety. os is caused by a large amount of reactive oxygen species or impaired enzymatic or non-enzymatic defense against it. os has been suggested to contribute to etiology of mentioned disorders. this review int...

BACKGROUND Multiple studies document the beneficial effect of midazolam on preoperative anxiety in children. Many clinicians report, however, that some children may in fact not benefit from the administration of this drug. METHODS After screening for relevant exclusion criteria, children undergoing surgery were enrolled in the study (n = 262) and received 0.5 mg/kg oral midazolam at 20-40 min...

We have studied the incidence of apnoea after induction of anaesthesia in patients allocated randomly to receive a standardized dose of either propofol or etomidate. We measured anxiety before operation with a standard questionnaire and end-tidal carbon dioxide concentration from a mask during breathing 35% oxygen, before induction of anaesthesia. Respiration was measured by pneumotachograph an...

the effect of clonidine, a central alpha2-adrenoreceptor agonist on reduction of anxiety, producing sedation and attenuation hemodynamic changes, were assessed during thissemi-experimental study in one of the hospitals of iran medical sciences university in tehran, 1994.   fifty surgical patients of either sex, 18-60 years of age, with asa physical status i or ii, gave informed consent to enter...

This study explored using hypnosis for pain and anxiety management in 6 colonoscopy patients (5 men, 1 woman), who received a hypnotic induction and instruction in self-hypnosis on the day of their colonoscopy. Patients' levels of anxiety were obtained before and after the hypnotic induction using Visual Analogue Scales (VAS). Following colonoscopy, VASs were used to assess anxiety and pain dur...

objective(s): our previous studies have shown that mgo nanoparticles (mgo nps) could improve anxiety and reduce pain in animals. in this study, the effect of co administration mgo nps and vitamin c on anxiety like behavior and nociception in postpartum depression (ppd) model were investigated.materials and methods:  female mice (27 ± 3 g) were divided into groups: two control groups, ppd groups...