background :wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. we investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (hsv-1) in cell culture.   methods : in-vitro c...

background and aims: lemon balm l (lamiaceae) has been used in a variety of practical applications in medical sciences. its antiviral activity against herpes simplex virus type-1 (hsv-1) was investigated in cell culture. lemon balm hydroalcoholic extract was found to be non-toxic to vero cells up to concentration 800 ug/ml and inhibited the growth and development of hsv-1 in dose-dependent mann...

Hepatitis B Virus (HBV) is a causative agent of the most frequent viral infections of man. Since the non-human host range of HBV is restricted to a few animals, such as, chimpanzee, the development of new therapeutics for HBV has been hampered. Several cell lines were developed to identify potential therapeutics against HBV infection. One of these, the HepG2 2.2.15 cell line, was derived throug...

The synthesis of a series of purine analogues of the acyclonucleoside compound 14 (acyclovir) is described. Compounds in this series have been shown to have pronounced activity against herpes virus-type l(HSV-1). The anti-viral activities of other analogs whose syntheses were recently reported [1] by us are also described

Resveratrol is a natural compound produced by certain plants on various stimuli. In recent years, extensive research on resveratrol has been carried out, demonstrating its capacity to prevent a wide variety of conditions, including cardiovascular diseases and cancer, and to control fungal, bacterial and viral infections. In the present review, we summarize the current knowledge of the activity ...

In this research, dried acetone:chloroform extract of aerial parts of E. denticulata as one of the endemic plants to Iran, afforded a number of triterpenes and steroids including: betulin, 24-methylene-cycloart-3-ol, cycloart-23Z-ene-3β,25-diol, cycloart-23Z-ene-3β,25-diol, ergosta-8,24-dien-3-ol (obtusifoliol) and beta-sitosterol which were reported for the first time from this plant. The stru...

Background: Sodium valproate (VPA), an anticonvalsant drug, has been reported to stimulate viral replication.  A combination therapy with VPA and acyclovir (ACV) is used for the treatment of herpesvirus encephalitis, the commonest sporadic encephalitis of viral origin. Objective: To determine a possible interaction between VPA and ACV leading to a modification of antiviral activity of ACV. Meth...

A large number of plants have been used by various societies for the treatment of disease. Tagetes minuta L. (Asteraceae) is an annual species native of South American, although it has became widespread throughout the world. It is used in medicinal tea and condiments. Decoction of the plant is used as beverage and as a remedy for common cold, digestive system complaints, stomach upsets, diarrhe...