Background: Several therapeutic effects including anti-asthma and dyspnea have been described for Plantago lanceolata. In the present study the antitussive effect of this plant was evaluated. Methods: The antitussive effects of aerosols of two different concentrations of Soxhlet and macerated ethanolic extracts, codeine and saline were tested by counting the number of coughs produced due to aer...

Cough is the most common complaint for which outpatients in the United States seek medical attention, and yet available therapeutic options for cough lack proven efficacy and are further limited by safety and abuse liabilities. Thus, safe and effective cough suppressants are needed. Recent preclinical studies described the antitussive effects of memantine, an N-methyl-d-aspartate receptor chann...

The aim of this study was to analyze the expectorant, antitussive and antiasthmatic effects of asterosaponin from Luidia quinaria through secretion of phenol red from mouse tracheas, frequency of cough caused by ammonia in mice and asthma induced by histamine in guinea pig, respectively. Results showed that asterosaponin extracted from L. quinaria at doses of 20 mg/kg and 40 mg/kg could signifi...

In this study, the activity of the d-opioid receptor subtypeselective agonist, SB 227122, was investigated in a guinea pig model of citric acid-induced cough. Parenteral administration of selective agonists of the d-opioid receptor (SB 227122), m-opioid receptor (codeine and hydrocodone), and k-opioid receptor (BRL 52974) produced dose-related inhibition of citric acid-induced cough with ED50 v...

several therapeutic effects including hypnotic, antispasmodic, treatment of abdominal and chest pain and strengthening the heart have been described for the flowers of rosa damascena. north american indian tribes use a decoction of the roots obtained from the rosa damascena plant as a cough remedy and to treat eye problem. therefore, in the present study the antitussive effect of this plant in ...

BACKGROUND Cough is one of the most common symptoms for which patients seek medical attention from primary care physicians and lung specialists. About 40% of the population at any one time report cough. Cough is associated with significantly impaired health-related quality of life. Levodropropizine is an effective and very well tolerated peripheral antitussive drug. We want to compare it to cen...

We have previously shown that the caudal nucleus tractus solitarii is a site of action of some antitussive drugs and that the caudal ventral respiratory group (cVRG) region has a crucial role in determining both the expiratory and inspiratory components of the cough motor pattern. These findings led us to suggest that the cVRG region, and possibly other neural substrates involved in cough regul...

BACKGROUND Theophylline has been used in the treatment of asthma and chronic obstructive pulmonary disease for more than 80 years. In addition to bronchodilator and anti-inflammatory activity, clinical studies have suggested that theophylline acts as an antitussive agent. Cough is the most frequent reason for consultation with a family doctor, and treatment options are limited. Determining how ...