Owing to the persistence of tuberculosis (TB) as well as the emergence of multidrug-resistant and extensively drug-resistant (XDR) forms of the disease, the development of new antitubercular drugs is crucial. Developing inhibitors of shikimate kinase (SK) in the shikimate pathway will provide a selective target for antitubercular agents. Many studies have used in silico technology to identify c...

Recently, one third of the world’s population is infected with Mycobacterium tuberculosis and 8 million new and relapse cases of tuberculosis are reported every year. The emergence of new cases, the increased incidence of multidrug resistant strains of M. tuberculosis, and the adverse effects of first and second-line antituberculosis drugs have led to renewed research interest in natural produc...

A series of twenty new chloropyrazine conjugated benzothiazepines (22–41) have been synthesized with 58%–95% yields. The compounds were characterized by using different spectroscopic techniques including FT-IR, 1H NMR, 13C NMR spectroscopy and mass spectrometry. their precursor chalcones (2–21) evaluated for antitubercular cytotoxic activities. Additionally, 22–41 also tested antimicrobial acti...

Two cases of tuberculosis of the thoracic spine with extrapleural extension of paravertebral abscesses, presenting radiologically as cold abscesses away from the spine in the PA chest radiograph, are presented. The radiographic features and response to antitubercular drugs are discussed.

OBJECTIVES To evaluate a novel series of quinoxaline 1,4-di-N-oxides for in vitro activity against Mycobacterium tuberculosis and for efficacy in a mouse model of tuberculosis (TB). METHODS Ketone and amide derivatives of quinoxaline 1,4-di-N-oxide were evaluated in in vitro and in vivo tests including: (i) activity against M. tuberculosis resistant to currently used antitubercular drugs incl...

Pawan Kumar Mishra*, Jaya Dwivedi, Rajani Chauhan Department of Pharmacy, Vishveshwarya Group of Institutions, Dadri, Gautam Budh Nagar (U.P.), 203207. Department of Pharmaceutical Chemistry, Banasthali University, P.O. Banasthali Vidyapith (Rajasthan)-304022, India Department of Pharmacy, Banasthali University, P.O. Banasthali Vidyapith (Rajasthan)-304022, India *Corresponding author: pkmpharm...

Keeping in view the drawbacks associated with research on anti-TB drugs based on plant extracts and the non-availability of fluorinated natural products with antitubercular activity has prompted us to make an effort towards the synthesis and characterization of a novel series of fifteen substituted fluorobenzimidazoles. The newly synthesized compounds were characterized by I.R, 1H-NMR, 13C-NMR,...

Compounds originally designed as putative tubulin inhibitors were tested as antitubercular agents for inhibition of the Mycobacterium tuberculosis analogue of tubulin, FtsZ. Initial screening of 200 2-alkoxycarbonylpyridines found several that inhibited M. tuberculosis growth. Two compounds, SRI-3072 and SRI-7614, inhibited FtsZ polymerization and were equipotent against susceptible and single-...