background: the rosemary extract (re) possesses various antioxidant, cytoprotective and cognition-improving bioactivities. in this study, we postulated which doses of re have a more effect on the hippocampus of middle-aged rats.   methods : in this experimental study, thirty-two middle-aged male wistar rats were fed by different doses (50,100 and 200 mg/kg/day) of re (containing 40% carnosic ac...

Dietary antioxidants protect laboratory animals against the induction of tumors by a variety of chemical carcinogens. Among possible media nisms, protection against chemical cardnogenesis could be mediated via antioxidant-dependent induction of detoxifying enzymes. Therefore, we investigated the effects of two commonly used food preservatives, butyl ated hydroxyanisole (BHA) and butylated hydro...

Biochemical and molecular analysis of some antioxidant enzyme genes revealed different level of gene expression on oilseed (Brassica napus). For molecular and biochemical analysis, leaf tissues were harvested from plants at eight different developmental stages, from young to senescence. The levels of total protein and chlorophyll were increased during maturity stages of plant, while these were ...

Doxorubicin (Dox) is a highly effective antineoplastic antibiotic associated with a dose-limiting cardiotoxicity that may result in irreversible cardiomyopathy and heart failure. The purpose of this study was to examine the effects of low-intensity exercise training (LIET) during the course of Dox treatment on cardiac function, myosin heavy chain expression, oxidative stress, and apoptosis acti...

The brain's anti-oxidant response to highly elevated oxygen (O2) partial pressures is poorly understood. In this study we hypothesized that hyperbaric O2 (HBO2) would stimulate superoxide dismutase (SOD) transcription in the oxidative stress-sensitive rat hippocampus and measured the time course and extent of the changes in hippocampal mRNA for all three SOD isoforms and total SOD enzyme activi...

Human d-aspartate oxidase (hDASPO) is a FAD-dependent enzyme responsible for the degradation of (d-Asp). In mammalian central nervous system, d-Asp behaves as classical neurotransmitter, it thought to be involved in neural development, brain morphology and behavior, appears several pathological states, such schizophrenia Alzheimer's disease. Apparently, human DDO gene produces alternative trans...

heavy metal pollution is a worldwide problem with serious environmental consequences. the objective of the present experiment was to investigate whether arginine as nitric oxide precursor and or polyamines substrate can decrease the destructive effects of oxidative stress induced by nickel contamination in hyoscyamus niger plant. in this study the effects of arginine pretreatment on alkaloid co...