independent pathways. through both phoP-dependent and RpoS (sigma(S)) independent and occurs polymyxin B in Salmonella typhimurium is resistance to the antimicrobial peptide Starvation-and Stationary-phase-induced

The need for novel antibiotics in an era where antimicrobial resistance is on the rise, and the number of new approved antimicrobial drugs reaching the market is declining, is evident. The underused potential of post-translationally modified peptides for clinical use makes this class of peptides interesting candidates. In this study, we made use of the vast amounts of available genomic data and...

Virulent group A streptococci have become a serious threat, with the emergence of the hypervirulent lineage M1T1. In this issue of Cell Host & Microbe, LaRock et al. (2015), uncover a role for the streptococcal M1 protein in neutralizing a key human antimicrobial peptide, cathelicidin.

Recently, an anionic proregion was found to be conserved at the C terminus of the antimicrobial peptide, nematode cecropin. Our results suggest that the antimicrobial activity of mature peptide is suppressed by the proregion in its precursor and is released from inhibition after processing. Inhibition is not likely to be due to direct suppression of membrane disruption.

The Identification of a Novel Peptide Derived from Lactoferrin Isolated Camel Milk with Potential Antimicrobial Activity

objectives in this study, we reported the identification of a cdna sequence encoding cysteine-free antimicrobial peptides isolated from venomous glands of this species. materials and methods total rna was extracted from the iranian mesobuthus eupeus venom glands, and cdna was synthesized by using the modified oligo (dt). the cdna was used as the template for applying semi-nested rt- pcr techniq...

Adolescents with low motor competence have diminished perceptions of their physical self and tend to avoid physical activities. This study examined the outcomes of an exercise intervention that focused on improving aerobic fitness, strength, and self-perceptions in the physical domain in adolescents with poor motor coordination. The sample included 35 adolescents with low motor competence, comp...