AIMS To assess the pattern of use of antimetabolites in trabeculectomy surgery by all consultant ophthalmologists in the United Kingdom. METHODS A postal questionnaire of 12 questions regarding antimetabolite use in trabeculectomy surgery was sent to all 749 consultant ophthalmologists in the United Kingdom. The consultants were asked to estimate the number of trabeculectomies they performed ...

The lack of new antibiotics coupled with the increased prevalence of multidrugresistant bacterial pathogens is cause for great concern (Wright, 2012). The genomics revolution predicted a new era in antibiotics discovery with the delivery of an abundance of conserved and essential targets (Payne et al., 2007). However, target-based approaches for antibacterial discovery have proven quite challen...

Anticancer drugs are a group of therapeutic agents used to enhance cell death in targeted types neoplasia. Because frequent use and eventual discharge, they have been often detected wastewater from pharmaceutical factories hospitals, domestic wastewater, surface waters. The occurrence these aquatic ecosystems their effects on organisms poorly characterized. This review focuses the global major ...

Here we report that GNE-783, a novel checkpoint kinase-1 (CHK1) inhibitor, enhances the activity of gemcitabine by disabling the SandG2 cell-cycle checkpoints followingDNAdamage. Using a focused library of 51 DNA-damaging agents, we undertook a systematic screen using three different cell lines to determine which chemotherapeutics have their activity enhanced when combined with GNE-783. We foun...

Pancreatic cancer is a deadly and aggressive disease. Less than 1% of diagnosed patients survive 5 years with an average survival time of only 4-8 months. The only option for metastatic pancreatic cancer is chemotherapy where only the antimetabolites gemcitabine and 5-fluorouracil are used clinically. Unfortunately, efforts to improve chemotherapy regimens by combining, 5-fluorouracil or gemcit...

PURPOSE To assess the long-term safety and effectiveness of non penetrating deep sclerectomy (DS) and to compare the incidence and the severity of postoperative complications and the IOP results according to surgical adjuvants (implant device, antimetabolite or both) were used or not. MATERIAL-METHODS Retrospective non randomised study including 171 eyes (136 patients), mean age: 63.9 years) ...