India contributes significantly to the global Plasmodium vivax burden. Treatment of malaria is more challenging than before owing rise antimalarial drug resistance. The commonly used drugs for treatment are chloroquine, antifolates like sulfadoxine-pyrimethamine, and artemisinin-based derivatives. Antimalarial resistance studied by in vitro vivo methods. Study on mutations targets parasite a wi...

the formation of hemozoin (malaria pigment) has been proposed as an ideal drug target for antimalarial screening programs. in this study, we used an improved, cost-effective and high-throughput spectrophotometric assay to screen plant extracts for finding novel antimalarial plant sources. fifteen extracts with different polarity from three iranian artemisia species, a. ciniformis, a. biennis an...

Fifteen novel β-lactams bearing the N-ethyl tert-butyl carbamate group 5a-o and fifteen N-(2-aminoethyl) β-lactams 6a-o were synthesized by the ketene-imine [2+2] cycloaddition reaction (Staudinger ). The cycloaddition reaction was found to be totally diastereoselective leading exclusively to the formation of the cis-β-lactam derivatives. These newly synthesized β-lactams were evaluated for the...

Background: Resistance to most antimalarial drugs has encouraged the development of novel drugs. An alternative source for discovering such drugs is natural products. Some Ferulago species are used in folk medicine for their sedative, tonic and anti-parasitic effects. Besides, coumarins isolated from this genus found to have in vitro anti-leishmanicidal effect. The present study is aimed to eva...

Background: Resistance to most antimalarial drugs has encouraged the development of novel drugs. An alternative source for discovering such drugs is natural products. Some Ferulago species are used in folk medicine for their sedative, tonic and anti-parasitic effects. Besides, coumarins isolated from this genus found to have in vitro anti-leishmanicidal effect. The present study is aimed to eva...

Malaria, one of the most widespread diseases, is caused by a plasmodium parasite million people each year, results in several million deaths annually. protozoa that cause malaria, no one antimalarial drug is effective against all four species. research investigation, we performed antimalarial agents. To design a new molecule having good pha information. Key-words: TPSA, GPCR, ADMETox, Malaria i...

Continual exposure of malarial parasite populations to different drugs may have selected not only for resistance to individual drugs but also for genetic traits that favor initiation of resistance to novel unrelated antimalarials. To test this hypothesis, different Plasmodium falciparum clones having varying numbers of preexisting resistance mechanisms were treated with two new antimalarial age...