Antidepressants are indicated in about 40 different disorders, including mood disorders, anxiety disorders, and other disorders. We propose to call these disorders antidepressani-responsive disorders (ARDs). We describe the clinical and biological criteria that differentiate the antidepressants. Although antidepressants share the same clinical efficacy in most ARDs, the configuration of adverse...

antidepressant agents inhibit the neuronal reuptake of monoamines such as serotonin (5-ht), noradrenaline (na), and dopamine (da). several clinical and animal studies have advocated the use of these agents in the management of pain. in this study, therefore, the possibility of a correlation between the analgesic activity of six serotonin specific reuptake inhibitor (ssri) antidepressants and th...

background: migraine is a chronic  neurological  disorder, characterized  by recurrent  moderate to severe headaches. worldwide migraine a=ects nearly 15%. studies suggest that genes involved in the production of nitric oxide (no) may act as genetic  factors for migraine. no synthase  3 (nos3) by expressing  enzyme nos regulates  endothelial  derived no. one  class of  medications   used  as  f...

OBJECTIVE This study reviewed the evidence from randomized, controlled trials on the efficacy and safety of antidepressants in the short-term treatment of bipolar depression. METHOD The authors performed a systematic review and meta-analysis of randomized, controlled trials. They searched the Cochrane Collaboration Depression, Anxiety, and Neurosis Controlled Trials Register, incorporating re...

depression is a serious disorder in today’s society, with the estimates of lifetime prevalence being as high as 21% of the general population in some developed countries. as defined by the american psychiatric association, depression is a heterogeneous disorder often manifested with symptoms at the psychological, behavioral, and physiological levels. such patients are often reluctant to take sy...