objective(s) this study planned to assess antidepressant like activity of aqueous extract from leaves of citrus maxima merr. (rutaceae). materials and methods boiling was used for aqueous extraction. acute toxicity study was performed in mice. antidepressant activity was studied using locomotor activity test, modified forced swimming test (fst) and tail suspension test (tst). three doses 100, 2...

Antidepressant augmentation strategies are commonly employed to treat depressed patients who do not respond to antidepressant monotherapy. Neuroinflammatory mechanisms have been implicated in depression, and nonsteroidal anti-inflammatory drugs (NSAIDs) have been found effective in animal models of depression both in monotherapy and when used to augment antidepressant drugs. However, results wi...

FOR HKMA Antidepressant drugs have unique toxicities that are based on their pharmacology and determine their specific treatment. There are currently 4 classes of antidepressant drugs: monoamine oxidase inhibitors, cyclic antidepressants, selective serotonin reuptake inhibitors, and the atypical antidepressants which include a variety of other drugs. The selective serotonin reuptake inhibitors ...

Affective disorders are a group of psychiatric diseases that can affect an individual at any given age. Also called mood disorders, they can be distinguished into two different types: major depressive disorder, also called major depression, and bipolar disorder, which is known as manic depression. People affected by major depression most often have a low mood, and are consistently in a state of...

The catecholamine hypothesis of depression postulates a deficiency of norepinephrine at functional receptor sites. The evidential basis derives from studies on the turnover and uptake of norepinephrine and the blockade of reuptake by tricyclic antidepressants El 3]. Serotonin systems may also be involved in antidepressant drug action [4, 5]. Relatively little attention has been paid to the poss...

anti-inflammatory activity has been reported for a few of antidepressant drugs and in contrary sertraline has potentiated inflammation. in this study, anti-inflammatory effect of a collection of antidepressant drugs belonging to different classes was evaluated to help a rational selection of these drugs in disease conditions such as association of depression or anxiety with inflammatory disease...

Depressive symptoms and depressive illness are associated with impairments in sexual function and satisfaction but the findings of randomised placebo-controlled trials demonstrate that antidepressant drugs can be associated with the development or worsening of sexual dysfunction. Sexual difficulties during antidepressant treatment often resolve as depression lifts but may persist over long peri...

BACKGROUND The safety and tolerability of the selective serotonin reuptake inhibitors and the newer atypical agents have led to a significant increase in antidepressant use. These changes raise concern as to the likelihood of a corresponding increase in adverse behavioral reactions attributable to these drugs. METHOD All admissions to a university-based general hospital psychiatric unit durin...