A comparison of the anticonvulsant and neurotoxic effects of cannabidiol (CBD), delta 9tetrahydrocannabinol, cannabinol and antiepileptic drugs (phenytoin, phenobarbital, carbamazepine, chlordiazepoxide, clonazepam, ethosuximide and trimethadione) was made in rats. Median effective potencies (ED 50 values) for maximal electroshock, audiogenic seizures and TD50 values for a rotor rod neurotoxici...

Inosine (INO) has an anticonvulsant effect against seizures induced by antagonists of GABAergic system. Quinolinic acid (QA) is an agonist NMDA receptors implicated in the neurobiology of seizures. In the present study, we investigated the anticonvulsant effect of intracerebroventricular (i.c.v.) INO administration against QA-induced seizures in adult mice. We also investigated whether the benz...

It was previously reported that systemic administration of dipyrone inhibited the tonic component of generalized tonic-clonic seizures in both the electroshock and the audiogenic seizure models. The aim of the present study was to investigate the mechanisms involved in the anticonvulsant action of dipyrone by assessing the role of nitric oxide and opioids in the electroshock (female 60- to 90-d...

Some novel fluorinated quinazolines (5a-j) were designed and synthesized to be evaluated for their anticonvulsant activity and their neurotoxicity. Structures of all newly synthesized compounds were confirmed by their infrared (IR), mass spectrometry (MS) spectra, ¹H nuclear magnetic resonance (NMR), 13C-NMR, and elemental analysis (CHN). The anticonvulsant activity was evaluated by a subcutane...

methyl indole derivative of some 6-aryl-4,5-dihydropyridazin-3(2h)-ones (3a-e) were synthesized by mannich reaction and evaluated as anticonvulsant against mes (50ma, for 2sec), inh (250mg/kg), scptz (80mg/kg) and str (3mg/kg) induced convulsion methods at 50 mg/kg dose level. all compounds 3a-e were also evaluated as antitubercular agent against m. tuberculosis h37rv by maba method. all compou...

this study investigated the anticonvulsant activity and possible mechanism of action of an aqueous solution of dorema ammoniacum gum (dag) which has been used traditionally in the treatment of convulsions.in this study, the anticonvulsant activity of dag was examined using the pentylentetrazole (ptz) model in mice. thirty male albino mice were divided randomly and equally to 5 groups, and pretr...

the anticonvulsant activity of astragalus squarrosus total extract was assessed in pentylenetetrazole (ptz)-induced convulsion in mice, with diazepam as the standard drug, while mechanistic studies were also conducted using flumazenil, a gaba a-benzodiazepine receptor complex site antagonist. the extract produced protection against convulsion at 400 mg/kg, comparable with protection of benzodia...

Considerable interest has been focused on the triazole structure, which has been known to possess a broad spectrum of biological activities such as antitumor, anti-inflammatory, antimicrobial, antiviral, and anticonvulsant activities. Before this, several heterocyclic compounds containing triazole were synthesized that had shown considerable anticonvulsant activity. As part of our continuous re...

A variety of observations suggest that decreasing glycolysis and increasing levels of reduced glutathione, generated by metabolism of glucose through the pentose phosphate pathway, would have an anticonvulsant effect. Because fructose-1,6-bisphosphate (F1,6BP) shifts the metabolism of glucose from glycolysis to the pentose phosphate pathway, it was hypothesized to have anticonvulsant activity. ...