OBJECTIVE To evaluate the frequency of clinical and laboratory manifestations in patients with primary antiphospholipid syndrome (PAPS) with positive antinuclear antibodies (ANA Hep-2+) compared to those in whom this antibody is negative (ANA Hep-2-). PATIENTS AND METHODS This is a transversal study with 58 patients (82.8% females) with PAPS. Demographic and clinical data, comorbidities, medi...

OBJECTIVE To investigate the prevalence and normal versus abnormal levels of anticardiolipin antibodies (aCL) in a healthy adult population of Omanis and whether a correlation exists between aCL and antinuclear antibodies (ANA) in this Omani population. METHODS A total of 521 healthy Omani individuals (333 males and 188 females), aged between 17-54-years were investigated for the presence and...

OBJECTIVE To determine whether high levels of antibodies against the phospholipid beta2-glycoprotein I (beta2-gpI) cofactor are associated with an increase in the risk of acute myocardial infarction. METHODS The study comprised 82 patients with acute myocardial infarction and 82 controls, who were assessed in regard to age, sex, race, hypertension, smoking, previous heart disease, history of ...

Quantitative isotype specific enzyme linked immunosorbent assay (ELISA) was used to determine the distribution of immunoglobulin isotypes and phospholipid specificities of anticardiolipin (anti-CL) antibodies in 40 patients with one or more of the following 'antiphospholipid (anti-PL) antibody associated clinical complications'--namely, thrombosis, fetal loss, thrombocytopenia. Twelve of 40 pat...

OBJECTIVE To evaluate the association of IgG and IgM antibodies directed against different negatively charged phospholipids (that is, anticardiolipin (aCL), antiphosphatidylinositol, antiphosphatidylserine, and antiphosphatidic acid) and anti-beta(2)-glycoprotein I (abeta(2)GPI), with Raynaud's phenomenon in patients with systemic lupus erythematosus (SLE). METHODS Ninety three patients with ...

BACKGROUND The association of anticardiolipin (aCL) antibodies with coronary artery disease has been shown in several studies but remains controversial. We evaluated the association of aCL and anti-beta(2)-glycoprotein I (abeta(2)GPI) antibodies with the risk of recurrent cardiac events in postinfarction patients. METHODS AND RESULTS The study population consisted of 1150 patients with acute ...

Methods 58 JIA patients were vaccinated with cepa A/California/ 7/2009 (NYMC X-179A) anti-H1N1. All participants received 1 dose of immunization, those <9yrs of age received a second dose 3weeks apart. All sera were evaluated before and 3weeks after complete vaccination. Serology against H1N1 virus was performed by hemagglutination inhibition antibody assay, antinuclear antibodies (ANA) by IIF,...

BACKGROUND Research on autoantibody formation in patients treated with TNF alpha inhibitors has produced contradictory results. OBJECTIVE To study the prevalence of autoantibodies in patients with rheumatoid arthritis treated with the TNF alpha inhibitor infliximab. METHODS 53 patients (48 female, 11 male) treated with infliximab for rheumatoid arthritis were followed for autoantibody produ...

INTRODUCTION Acute myocardial infarction (AMI) will probably remain the most important cause of death over the next decades. Traditional risk factors of atherosclerosis could not exactly explain the development of acute coronary events such as AMI. Antiphospholipid antibody syndrome is a disorder characterized by the development of arterial and venous thrombosis. AIM In this study, we investi...