The antibiotic treatment of severe sepsis poses an increasing challenge in ICU. The multidrug resistance and diverse pharmacokinetics of antibiotics requires a different approach on antibiotic therapy because of the inadequate serum antibiotic levels found in ICU patients. The current guidelines or recommendations of antibiotic treatment take into account the pharmacokinetic parameters in deter...

conclusions based on our findings, p. aerugionsa is a major causative agent of wound infections and amikacin could be considered as a more effective antibiotic for treatment of the burned patients. background nowadays, the treatment of burned patients is difficult because of the high frequency of infection with antibiotic resistance bacteria. objectives this study was conducted to evaluate the ...

introduction: wastewater treatment plants are important hotspots for the spread of  antibiotic resistance genes to the environment.  the aim of this study identification of relevant antibiotic resistance genes  in raw  and final effluent of municipal wastewater treatment and also determination of effects of different wastewater treatment process on removal/reduction of these pollutants. materia...

BACKGROUND Appropriate antibiotic treatment decreases mortality, while superfluous treatment is associated with antibiotic resistance. We built a computerized decision support system for antibiotic treatment (TREAT) targeting these outcomes. METHODS Prospective cohort study comparing TREAT's advice to physician's treatment followed by a cluster randomized trial comparing wards using TREAT (in...

Antibiotic overuse has created a problem with increased antibiotic resistance of disease-causing microorganisms. Prophylactic usage in dentistry contributed to this and adverse events like Clostridioides difficile infection. prescribing practices need review, so do treatment options for patient care the post-antibiotic age. Hydrogen peroxide is an example antimicrobial that can treat anaerobic ...