Powdery mildew is a common, economically important disease in the wheat growing area of Serbia. A large-scale virulence survey its causal agent Blumeria graminis f. sp. tritici population was performed period 1995–2013. total 1013 isolates were recovered from collected chasmothecial samples. Among them, 862 unique pathotypes identified using differential set 20 lines with known powdery (Pm) res...

Transmissible spongiform encephalopathies (TSEs) are caused by infectious agents with stable virulence characteristics that are not encoded by the host. Agent-specific features of virulence include variable disease latency and tissue pathology in a given host, as well as the ability to spread to many species. Such cross-species infections contradict predictions based on the prion hypothesis. Re...

Pseudomonas aeruginosa is an opportunistic pathogen that orchestrate its disease manifestation via a complex communication system known as quorum sensing (QS). Under the regulation of this network QS system, myriad virulence factors including flagella and pili contribute to motility. To establish infection in host, P. must first attach itself host cells with assistance it would be mere impossib...

The ppGpp molecule is part of a highly conserved regulatory system for mediating the growth response to various environmental conditions. This mechanism may represent a common strategy whereby pathogens such as Yersinia pestis, the causative agent of plague, regulate the virulence gene programs required for invasion, survival and persistence within host cells to match the capacity for growth. T...

Due to the continued growth of antibiotic-resistant Staphylococcus aureus strains, it is necessary explore alternative targets for future therapeutic applications. For this reason, important understand staphylococcal immune evasion mechanisms with a special focus on extracellular fibrinogen-binding protein (Efb) and Efb related proteins. Therefore, was conducted literature review compile releva...

background: advantages of herbal drugs have been known to human being for many years and they have been used for treatment of many diseases. nowadays, inflammation is known to be one of the basic pathologic causes of the diseases. objective: in this study the anti-inflammatory effect of thymus kotschyanus boiss & hohen was investigated. methods: forty two wistar rats were used in three divided ...

lisinopril dihydrate (angiotensin converting enzyme inhibitor) is a lysine derivative of enalaprilat and does not require hydrolysis to exert pharmacological activity. it has an extensive hepatic first pass metabolism resulting in a bioavailabil-ity of 6-60%. to overcome the poor bioavailability of the drug, transdermal patches have been prepared. the present study also aims at optimization of ...

Increasing antibiotic resistance urgently requires novel therapeutic options to combat bacterial infections. The anti-virulence therapy selectively intervening with pathogenicity without affecting bacterial viability is such a strategy to overcome resistance. We consider the virulence regulator PqsR as an attractive target in the human pathogen Pseudomonas aeruginosa, and recently discovered th...

Xanthomonas oryzae pv. oryzae is the causal agent of rice bacterial blight disease. Numerous genes critical for virulence have been identified. This article reviews current knowledge on the molecular mechanisms of X. oryzae pv. oryzae virulence.