The Dayak tribe are the indigenous people of West Kutai, East Kalimantan, Indonesia, and they have experiences in using plants for traditional medicine commonly used include Baccaurea macrocarpa (Miq.) Müll.Arg., Entada phaseoloides (L.) Merr., Goniothalamus macrophyllus (Blume) Hook.f. & Thomson, Gynura crepidioides Benth., Helicia robusta (Roxb.) R. Br var. robusta, Litsea elliptica, Pogo...

27 For screening of skin-whitening ingredients that modulate inhibition of melanogenesis, 28 tyrosinase promoter-based assay using a 3D spheroid culture technique is a beneficial tool to 29 improve the accuracy of raw material screening in cosmetics through mimicking of the in 30 vivo microenvironment. Although the advantages of high-throughput screening (HTS) are 31 widely known, there has bee...

To develop functional cosmetic material using <i>Rhodiola rosea</i>, the biological activities such as anti-oxidant, anti-inflammatory, astringent, anti-tyrosinase, and anti-elastase activity were investigated with methanol, <i>n</i>-hexane, chloroform, ethyl acetate, n-butanol, water fractions of <i>R. rosea</i> Root. DPPH ABTS radical scavenging acetate fra...

In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC(50) of mushroom tyrosinase inhibitory activity of 1 was 76.3 microM. The results of the comparison with ...

For screening of skin-whitening ingredients that modulate inhibition of melanogenesis, tyrosinase promoter-based assay using a three-dimensional (3D) spheroid culture technique is a beneficial tool to improve the accuracy of raw material screening in cosmetics through mimicking of the in vivo microenvironment. Although the advantages of high-throughput screening (HTS) are widely known, there ha...

In this study, the authors investigated the anti-melanogenic effects of 3,8-dihydroxyquinoline (jineol) isolated from Scolopendra subspinipes mutilans, the mechanisms responsible for its inhibition of melanogenesis in melan-a cells, and its antioxidant efficacy. Mushroom tyrosinase activities and melanin contents were determined in melan-a cells, and the protein and mRNA levels of MITF, tyrosin...

We report herein anti-proliferation effects of 4-arylthiosemicarbazides, with a cyclopentane substitution at N1 position, on highly virulent RH strain Toxoplasma gondii. Among them, the highest in vitro anti-Toxoplasma activity was found meta-iodo derivative. Further experiments demonstrated inhibitory thiosemicarbazides tyrosinase (Tyr) activity, and good correlation between percentage Tyr inh...

The development of melanogenic inhibitors is important for the prevention of hyperpigmentation, and, recently, consideration has been given to natural materials or traditionally used ingredients such as Chinese medicine. The aim of this study is the evaluation of a new anti-melanogenic candidate, kadsuralignan F, from the natural plant Kadsura coccinea, as well as the determination of mechanism...

BACKGROUND The purpose of the study was to determine the anti-melanogenic and anti-oxidant properties of Gaillardia aristata flower extract (GAE). METHODS Melanogenesis inhibition by GAE was investigated in cultivated cells and in a human skin model. In cultivated cells, the melanogenesis regulatory effect of GAE was evaluated using melanin content, intracellular tyrosinase activity and anti-...

Background: Aging is a process caused by oxidants and aging-related enzymes. Therefore, the inhibition of these processes can exacerbate anti-aging agents. This study aimed to evaluate antioxidant activities leaf extracts from seven herbs used in traditional Thai herbal remedies. Methods: Researchers assessed total levels phenolic content (TPC), antioxidant, anti-collagenase, anti-tyrosinase ac...