objective(s): tyrosinase is a key enzyme in pigment synthesis. overproduction of melanin in parts of the skin results in hyperpigmentation diseases. this enzyme is also responsible for the enzymatic browning in fruits and vegetables. thus, its inhibitors are of great importance in the medical, cosmetic and agricultural fields. materials and methods: a series of twelve kojic acid derivatives wer...

Overproduction and stimulation of tyrosinase result in increased melanogenesis of which several skin disorders such as freckles, spots, and hyperpigmentation appear as complications. Limonium tetragonum is a halophyte well-known for its antioxidative properties. This study investigated the anti-melanogenic effects of solvent-partitioned L. tetragonum extracts (LTEs) and its bioactive constituen...

The alcoholic extract from seed kernels of Thai mango (Mangifera indica L. cv. 'Fahlun') (Anacardiaceae) and its major phenolic principle (pentagalloylglucopyranose) exhibited potent, dose-dependent inhibitory effects on tyrosinase with respect to L-DOPA. Molecular docking studies revealed that the binding orientations of the phenolic principles were in the tyrosinase binding pocket and their o...

Functional foods to prevent aging, particularly skin have grown in popularity as society ages and science uncovers the pathological mechanisms of aging. In this study, we used processed ginseng, one famous functional foods, along with fermentation utilizing novel Aspergillus niger strain KHNT-1 enhance its value efficacy. We successfully produced fermented black ginseng (FBG) investigated anti-...

Recent studies have shown that plumbagin has anti-inflammatory, anti-allergic, antibacterial, and anti-cancer activities; however, it has not yet been shown whether plumbagin suppresses alpha-melanocyte stimulating hormone (α-MSH)-induced melanin synthesis to prevent hyperpigmentation. In this study, we demonstrated that plumbagin significantly suppresses α-MSH-stimulated melanin synthesis in B...

Nepeta glomerulosa Boiss. is a medicinal plant has been used in traditional medicine. The aim of this study was to evaluate the anti-melanogenesis inhibitory activity of MeOH, n-hexane, ethyl Acetate (EtAc), dichloromethane (CH2Cl2), n-butanol (BuOH) and H2O extracts isolated from N. glomerulosa in B16 melanoma cell line. The B16F10 cell line viability after treatment with increasing concentrat...

Objective(s): Tyrosinase is a key enzyme in pigment synthesis. Overproduction of melanin in parts of the skin results in hyperpigmentation diseases. This enzyme is also responsible for the enzymatic browning in fruits and vegetables. Thus, its inhibitors are of great importance in the medical, cosmetic and agricultural fields. Materials and Methods: A series of twelve kojic acid derivatives wer...

tyrosinase is a multifunctional oxidase that is widely distributed in nature. it is a key enzyme in melanin biosynthesis and is involved in determining the color of mammalian skin and hair. in addition it is responsible for the undesirable enzymatic browning that occurs in plant-derived foods, limiting the shelf -life of fresh-cut products with the resultant economic loss.  in recent years ther...

Melanin protects the skin against UV damage, whereas excessive melanin accumulation causes abnormal pigmentation and even melanoma. It has been reported that Rosa rugosa exhibits antioxidant, anti-bacterial, anti-tumor, anti-inflammation activities. The current study evaluated melanogenesis-suppressing effect of R. extract its solvent fractions (H2O, n-BuOH, 85% aq. MeOH, n-hexane). on extra/in...

Background and objectives: Dried pulps and peels of Ziziphus jujuba fruits are commonly applied as food because of their high nutritional value. It has been widely used in traditional medicine as laxative, tonic, wound healing agent and appetizer. The aim of this study was to evaluate the anti-melanogenic effects of Z. jujuba fruit. Methods: </st...