objective(s):recently anti-inflammatory effects of antidepressants have been demonstrated. venlafaxine belongs to newer antidepressants with serotonin norepinephrine reuptake inhibition property. the pain alleviating properties of venlafaxine in different pain models such as neurogenic pain, diabetic neuropathy, and fibromyalgia have been demonstrated. anti-inflammatory effects of venlafaxine a...

A growing area of research is focused on cancer therapy, and new therapeutic approaches are welcomed. Mesenchymal stem cell (MSC)-based gene therapy is a promising strategy in oncology. Intrinsic tropism and migration to tumor microenvironment with off lights are attractive features of this type of cell carrier. In this way, suicide genes have also found a good platform for better performance a...

Geraniol is an acyclic monoterpenoid compound, which exists widely in aromatic plants. has antibacterial and anti-inflammatory effects. Recently, it been found that geraniol a strong effect on improving immune function anti-tumor. Many experimental evidences support good the treatment or prevention of different types tumors, such as breast cancer, lung liver pancreatic colon prostate etc. also ...

how to cite this article: talebian a, goudarzi rm, mohammadzadeh m , mirzadeh as. vincristine-induced cranial neuropathy. iran j child neurol. 2014 winter; 8(1):66-68.   abstract vincristine (vcr) is a vinca alkaloid that is used for treatment of many malignancies. the vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial neuropathies are rare as side effects.  de...

Background: Noradrenaline (NA), the principal neurotransmitter released from sympathetic nerve terminals, influences T-cell maturation, not only directly in developing T cells, but also indirectly, by acting on the thymic nonlymphoid cells. In vitro and in vivo studies have demonstrated the anti-proliferative, anti-migratory, antiangiogenic and cytotoxic properties of propranolol, β-AR blocker,...

Alpha-garactosylceramide (GalCer) has been shown to have anti-tumor effect in the basic research and clinical studies. However, anti-tumor effect of GalCer is limited. The administration of GalCer increases the production of IFN-γ which is involved in the suppression of tumor growth. On the other hand, the enhancement of IFN-γ production increases immunosuppressive factors such as nitric oxide....

Objective(s):Recently anti-inflammatory effects of antidepressants have been demonstrated. Venlafaxine belongs to newer antidepressants with serotonin norepinephrine reuptake inhibition property. The pain alleviating properties of venlafaxine in different pain models such as neurogenic pain, diabetic neuropathy, and fibromyalgia have been demonstrated. Anti-inflammatory effects of venlafaxine a...