there has been special interest in the chemistry of quinolone and pyrimidine derivatives due to their diverse biological activities such as anticonvulsant, anti-malarial agents, antibacterial, antiviral, cytostatic, antithelemintic, antigenotoxic, anti-cancer agents. these compounds are also used as targeting delayed-type hypersensivity and anti-convulsant agents. as a part of our research work...

Spondiasmombin is a widely cultivated edible plant used in folkloric medicine for the treatment of severe cough and other respiratory disorders. This study evaluated the anti tubercular property of the stem of S. mombin against Mycobacterium tuberculosis (H37Rv and EJA-2011) using agar proportion assay on Lowenstein-Jensen medium. Four new compounds were isolated from the stem of Spondiasmombin...

background & aim: considering the inevitable side effects of chemical drugs, nowadays, herbal medicine has gained a special importance. cinnamon of lauraceae family, is commonly used as a food spice and medicine. it is famous to be, antimicrobial, anti-oxidant, anti-diabetic, anti-viral, and antispastic. it also prevents abdominal bloating, increases sweating and uterus muscle constrictions...

a series of novel indeno[1, 2-b]quinoxalin-11-ylidenamines 2-9 have been synthesized via condensation of indane[1, 2-b]quinoxalin-11-one (1) with various primary aromatic amines in presence of acoh for 3 h. compound 1 was synthesized by condensation of indane-1,2,3-trione with benzene-1,2-diamine in presence of acoh. the synthesized compounds were characterized by ir, 1h-nmr, mass spectra and e...

A series of ethyl 2-[2-arylamino-4-(thiophen-2-yl)thiazol-5-yl] acetates (5a-5k) and ethyl 2-[2-(arylhydrazino)-4-(thiophen-2-yl)thiazol-5-yl] acetates (9a-9g) were synthesized and screened for their anti-inflammatory, analgesic, and antioxidant activities. In vivo test results showed that the compounds with halogen substitution (5c, 5g, 5h, 5i and 5j) at the para position on the 2-aryl amino g...

hybrid-density functional theory (b3lyp/def2-tzvpp) based method and nbointerpretation were used to investigate the conformational behavior of 1,2-dihalodisilanes[halo=f (1), cl (2), br (3), i (4)]. the b3lyp/def2-tzvpp results showed that the anticonformations of compounds 1-4 are more stable than their corresponding gaucheconformations. the stability of the anti conformation compared to the g...