Dihydropyridines (DHPs) with carboxamides in the 3 and 5 positions show anti-tuberculosis activity. The purpose of the present study was to synthesize new DHPs that would possibly possess anti-tuberculosis activity. So a series of N-aryl-1,4-dihydropyridine-3,5-dicarboxamides (3-38) was prepared. They were screened as antitubercular agents against one type of fast growing Mycobacterium (M. smeg...

pyrazinamide resistance in Mycobacterium tuberculosis The first report from Japan Masahiro Kobayashi; Sadao Aoki; Takefumi Saito MD, PhD; Akio Aono,; Satoshi Mitarai, MD, PhD; Department of Clinical Laboratory, National Hospital Organization Ibarakihigashi Hospital, Ibaraki, Japan; Department of Internal Medicine, National Hospital Organization Ibarakihigashi Hospital, Ibaraki, Japan; Departmen...

background medicinal plants have been used traditionally in golestan province (north of iran), against mycobacterium tuberculosis or the clinical signs of tuberculosis (tb). objectives this study aimed to define the inhibitory effects of ethanolic extracts of six of these medicinal plants against mycobacterium tuberculosis. materials and methods peganum harmala (seed extract), punica granatum (...

The musculoskeletal extrapulmonary tuberculosis is uncommon, the upper extremity tuberculosis is not common and the mycobacterial involvement of skin of hands and synovial sheath of tendons is rare. This prospective observational study was undertaken between August  2014 and December 2015 in a tertiary referral hospital. Patients attending with suspected primary tuberculosis of soft tissue...

abstractchronic sialadenitis is a disease of salivary glands associated with chronic infections,systemic diseases and silolithiasis pathogenesis of the disease. primary tuberculoussubmandibulitis is not a reported disease. the diagnosis was confirmed whena 45 years old lady suspicious to submandibular gland tumor was operated on for excisionalbiopsy. histological examination of the specimen by ...

Tuberculosis and smoking are among the most pressing issues in modern health care system world. patients who smoke confirmed to have reduced effectiveness of anti-tuberculosis therapy, unsatisfactory prognosis a specific disease, higher risk treatment failure mortality from this disease. Diseases such as HIV alcoholism increase ineffective tobacco smokers. In addition, leads increased virulence...

Formation of biofilm in pathogenic bacteria defends them from antibiotics and the immune system of a host's life. Hence, investigation of the molecular mechanisms of biofilm formation and search for new substances counteracting this formation are becoming an attractive research area. In the course of our search for new inhibitors of biofilm formation in Mycobacterium species, we rediscovered a ...

Mycobacterium tuberculosis FabH, an essential enzyme in the mycolic acid biosynthetic pathway, is an attractive target for novel anti-tubercolosis agents. Structure-based design and synthesis of 1-(4-carboxybutyl)-4-(4-(substituted benzyloxy)phenyl)-1H-pyrrole-2-carboxylic acid derivatives 7a-h, a subset of eight potential FabH inhibitors, is described in this paper. The Vilsmeier-Haack reactio...

Mycobacterium tuberculosis is a leading cause of morbidity and mortality worldwide. Mycobacterium tuberculosis infects about one third of world population and tuberculosis remains the most frequent cause of death due to a single infectious disease. Anciently, herbal plants have established home remedies for many of common alignments, diagnostic procedures and preventive measures. Using this str...

A mixed infection of Mycobacterium abscessus subsp. abscessus (Mab) and Mycobacterium tuberculosis (MTB) in the lung is an unusual clinical manifestation and has not yet been reported. A 61-year-old woman had been treated for Mab lung disease and concomitant pneumonia, and was diagnosed with pulmonary tuberculosis (PTB). Despite both anti-PTB and anti-Mab therapy, her entire left lung was destr...