The potential of surfactant modified zeolites as adsorbents for mycotoxins and as carrier of the pharmaceutical drugs was investigated. Ochratoxin A OCHRA (mycotoxin) and diclofenac sodium DS (anti-inflamatory drug) were used as model substances. Surface of the clinoptilolite was modified with different amounts of quaternary ammonium ions (hexadecyltrimethyl ammonium HDTMA or octadecyldimethylb...

Inflammatory periapical lesions are characterized by infiltration of different immune cell types, the functions which depend on an effective vascular network. This study aimed to evaluate mast cells density (MCD) in inflamatory odontogenic cysts capsules concerning microvascular (MVD), area (MVA), and perimeter (MVP), correlate such findings with type lesion, intensity inflammatory infiltrate, ...

Interactions between cell surface receptors are important regulatory elements in the complex host responses to infections. In this study, it is shown that a classic chemotactic factor, the bacterial chemotactic peptide N-formyl-methionyl-leucylphenyl-alanine (fMLF), rapidly induced a protein-kinase-C-mediated serine phosphorylation and down-regulation of the chemokine receptor CCR5, which serve...

Background Inflammation is a response to external challenge or cellular injury that leads to the release of several inflammatory mediators and restoration of tissue structure and function. On the other hand, inflammation deregulation can cause tissue damage and is related to many diseases. During inflammation, a complex program of intracellular signal transduction and transcription events, driv...

Background: Midkine (MK) is a heparin-binding growth factor with promoting effects in inflammatory responses through enhancing leukocytes migration. Objective: To study the correlation between MK serum levels and concentration of inflammatory cytokines in Multiple Sclerosis (MS) patients. Methods: We evaluated the MK level and its relationship with inflammatory cytokines (IL-17 and IL-23) and a...

Triterpene saponins (saponosides) are found in a variety of higher plants and display a wide range of pharmacological activities, including expectorant, anti-inflamatory, vasoprotective, gastroprotective and antimicrobial properties. Recently, a potential anticancer activity of saponins has been suggested by their cytotoxic, cytostatic, pro-apoptotic and anti-invasive effects. At high concentra...

Objectives: The purpose of this work was development, formulation and testing of new herbal ointment for the treatment of mild to severe atopic dermatitis in infants and children (4 to 56 months old) as possible alternative therapy to standard corticosteroids and immunomodulants. Patients and methods: 50 patients were treated 8 weeks (every four hours) with the ointment containing the following...

Honey, propolis, and royal jelly, products originating in the beehive, are attractive ingredients for healthy foods. Honey has been used since ancient times as part of traditional medicine. Several aspects of this use indicate that it also has functions such as antibacterial, antioxidant, antitumor, anti-inflamatory, antibrowning, and antiviral. Propolis is a resinous substance produced by hone...