We have previously demonstrated that acacia polyphenol (AP) exerts strong anti-obesity, anti-diabetic, and anti-atopic dermatitis effects. In the present study, we investigated the anti-hypertensive effects of AP. Spontaneously hypertensive rats (SHR) with hypertension and control Wistar Kyoto rats (WKY) were used. WKY and SHR were fed AP-containing food or AP-free food (control group) ad libit...

Adlay (Coix larchryma-jobi L.) was the commonly used Traditional Chinese Medicine (TCM) with high content of seed storage protein. The hydrolyzed bioactive oligopeptides of adlay have been proven to be anti-hypertensive effective components. However, the structures and anti-hypertensive mechanism of bioactive oligopeptides from adlay were not clear. To discover the definite anti-hypertensive ol...

ABSTRAK Hipertensi adalah keadaan pada seseorang dimana terjadinya peningkatan tekanan darah yang melebihi batas normal telah ditentukan yaitu sistolik ≥ 140 mmHg dan diastolik 90 mmHg. Gaya hidup merupakan faktor utama meningkatkan penyakit hipertensi, salah satu penyebabnya kurang dalam melakukan aktifitas fisik, seperti olahraga. Salah fisik atau olahraga bisa dilakukan penderita hipertensi ...

Currently, herbs have been investigated for novel bioactivities and improvement of traditional therapeutic effectiveness. Among them, Andrographis paniculata, with the active component Andrographolide, is well recognized as an anti-inflammatory, anti-bacterial, anti-cancer, anti-hypertensive, anti-hyperglycaemic, hepatoprotective, anti-hyperlipidaemic compound. However, Andrographolide has poor...

INTRODUCTION Marked changes have been made in the pharmacotherapy of hypertension over the years. In sub-Saharan Africa, hypertension pharmacotherapy is often thought to include only thiazide diuretics, beta blockers and centrally acting medications and, it is unclear if and how often calcium channel blockers, angiotensin converting enzyme inhibitors and angiotensin receptor blockers are used. ...

1. A peripheral inhibitor of L-aromatic amino acid decarboxylase, carbidopa [(-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate], at doses up to 25 mg/kg intraperitoneally or 30 mg/kg orally had no effect on directly recorded arterial pressure of spontaneously hypertensive rats derived from the Wistar/Okamoto strain. It enhanced, however, the anti-hypertensive eff...