Microbial conversion of unsaturated fatty acids often leads to special changes in their product structures and in biological potential. In our continuous effort to screen natural products for their antimicrobial and enzyme inhibitor activities, we found that 10-hydroxy-8(E)-octadecenoic acid (HOD) exhibited strong anti-alpha-glucosidase (EC 3.2.1.20) activity. HOD is an intermediate in the bioc...

objective diabetes mellitus is manifested by hyperglycaemia. different treatments such as diets and drugs are recommended for diabetes control. for various reasons in recent years traditional plant (herbal) therapies as prescribed by indigenous systems of medicine with different mechanisms have commonly been used. the digestive enzymes such as alpha glucosidase are among these herbal remedies. ...

the imported willow leaf beetle, plagiodera versicolora is one of the main pests of forest trees worldwide including iran. activities of α- and β-glucosidases in the midgut of p. versicolora adults were studied in this research. the results showed a higher α- glucosidase activity of adultsthan β-glucosidase. the optimal phs for α- and β-glucosidases activities were found to be 6 and 9, respecti...

the majority of the antioxidant and antidiabetic activities of fruits are anthocyanins, a group of polyphenolics that are responsible for the color of many fruits, vegetables and flowers. the harvesting time, storage conditions, maturity, extraction steps etc. are very important for the biological activities based on the alteration of chemical composition. the free radical scavenging and antidi...

Miglitol is an alpha-glucosidase inhibitor that improves post-prandial hyperglycemia, and it is the only drug in its class that enters the bloodstream. Anecdotally, miglitol lowers patient body weight more effectively than other alpha-glucosidase inhibitors, but the precise mechanism has not been addressed. Therefore, we analyzed the anti-obesity effects of miglitol in mice and in the HB2 brown...

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by postprandial hyperglycemia, which is an early defect of T2DM and thus a primary target for anti-diabetic drugs. A therapeutic approach is to inhibit intestinal α-glucosidase, the key enzyme for dietary carbohydrate digestion, resulting in delayed rate of glucose absorption. Although tea extracts have been reported to have ...

Starting with L-tartaric acid the chiral 3,4-disubstituted pyrrolidine analogue sulfonamide derivatives were prepared. These compounds were examined for anti-bacterial and anti-fungal activity. Further the docking studies were carried out for the model compounds from each series against β-glucosidase and the results found are moderate. The structure–activity relationships are also briefly discu...

Validating ethnobotanical data from underexplored traditional plant remedies provides an infinite source of new pharmaceutical chemicals. The purpose this study was to determine the phytochemical composition and several biological activities (antioxidant, anti-lipase, anti-?-amylase, anti-?-glucosidase, antimicrobial) aqueous, ethanol, hexane, acetone Artemisia scoparia leaf extracts. An exhaus...

Pharmacognosy Research,2022,14,1,89-99.DOI:10.5530/pres.14.1.13Published:December 2021Type:Original ArticleAuthors:Mingkwan Rachpirom, Louis R Barrows, Suriyan Thengyai, Chitchamai Ovatlarnporn, Chonlatid Sontimuang, Pitchanan Thiantongin, and Panupong Puttarak Author(s) affiliations:Mingkwan Rachpirom1,2, Barrows3, Thengyai4, Ovatlarnporn5, Sontimuang6, Thiantongin7, Puttarak1,2,* 1Department ...

OBJECTIVE To evaluate the anti-hyperglycemic potential of sinigrin using in vitro, in silico and in vivo streptozotocin (STZ) induced hyperglycemic zebrafish model. METHODS The in vitro enzyme inhibition assay was carried out to determine the IC50 value against α-glucosidase and α-amylase, in silico molecular docking was performed against both enzymes with PyRx tool and simulations were perfo...