OBJECTIVES The relation between endothelium-dependent vasodilator function in the brachial and coronary arteries was determined in the same subjects. BACKGROUND Coronary artery endothelial dysfunction precedes the development of overt atherosclerosis and is important in its pathogenesis. A noninvasive assessment of endothelial function in a peripheral conduit vessel, the brachial artery, was ...

BACKGROUND A low ankle-brachial index (ABI) is associated with increased risk of coronary heart disease, stroke, and death. Regression model parameter estimates may be biased due to measurement error when the ABI is included as a predictor in regression models, but may be corrected if the reliability coefficient, R, is known. The R for the ABI computed from DINAMAP readings of the ankle and bra...

Study population The study population comprised a hypothetical cohort of previously untreated 60-year-old patients presenting with severe unilateral claudication of at least one year in duration, who had at least one significant lesion (>50% arterial diameter reduction) that was located predominantly suprainguinal or infrainguinal, an ankle brachial index pressure of 0.70 and no history of coro...

We investigated the cross-sectional relationship between ankle brachial index and cardiovascular disease risk factors, including C-reactive protein (CRP), among Japanese elderly, a topic which has had little prior epidemiologic study. Our study population comprised 946 subjects aged at least 70 years in whom both CRP and ankle brachial index were measured. The participants were classified into ...

iabetes mellitus (DM) is a major risk factor among typical coronary risk factors that must be considered in the primary and secondary prevention of coronary artery disease (CAD).1–3 The prognosis of diabetic patients without known CAD is reportedly similar to those with previous myocardial infarction.4,5 The diagnostic limitation for CAD in this high-risk group is that clinical symptoms are aty...

background: the prevalence of prediabetes in the world continues to increase. these patients have elevated the risk of atherosclerosis. the current study was designed to assess the prevalence of peripheral arterial disease (pad) and its related risk factors in prediabetes patients. methods: this was the case-control study in which 135 adults in three groups: diabetes, prediabetes, and normal we...

Peripheral arterial disease (PAD), diagnosed by decreased ankle-brachial index (ABI), is a major clinical problem, affecting 8% of people 60 to 69 years old and at least 18% of people over age 70 (1). A substantial minority of patients with PAD report intermittent claudication (IC) (2). As the population ages, IC is an increasingly common cause of disability, particularly in elderly women (3). ...

Ratio and Risk of Abnormal Ankle-Brachial Index in a Community-Based Chinese Population. J Atheroscler Thromb, 2012; 19: 912-917 2) Vassalle C, Bianchi S, Battaglia D, Landi P, Bianchi F, Carpeggiani C: Elevated levels of oxidative stress as a prognostic predictor of major adverse cardiovascular events in patients with coronary artery disease. J Atheroscler Thromb, 2012; 19: 712-717 3) Mizuno Y...

INTRODUCTION AND OBJECTIVES Detecting peripheral arterial disease by measuring the ankle-brachial index can help identify asymptomatic patients with established disease. We investigated the prevalence of peripheral arterial disease (i.e., an ankle-brachial index <0.9) and its potential clinical and therapeutic impact in patients with no known arterial disease who were seen at internal medicine ...