Yang R, Amir J, Liu H, Chaqour B. Mechanical strain activates a program of genes functionally involved in paracrine signaling of angiogenesis. Physiol Genomics 36: 1–14, 2008. First published October 14, 2008; doi:10.1152/physiolgenomics.90291.2008.—Studies were performed to examine the extent to which mechanical stimuli mediate control of angiogenesis in bladder cells both in vitro and in vivo...

1. Abstract 2. Introduction 3. Models for the study of aging and angiogenesis 4. Pathogenesis of impaired angiogenesis in aging 4.1. The microvasculature in aging 4.2. Pre-angiogenic vascular function 4.2.1. Vasodilation: Pre-angiogenic supply-demand vascular compensation 4.2.2. Hemostatic proteolytic cascades: Pre-angiogenic vascular self-defense 4.3. Growth factors in aging 4.3.1. Vascular en...

The ECM protein Del-1 is one of several novel ECM proteins that accumulate around angiogenic blood vessels in embryonic and tumor tissue and promote angiogenesis in the absence of exogenous growth factors. Del-1 expressed in mouse or rabbit ischemic hind-limb muscle by gene transfer rapidly promotes new blood vessel formation and restores muscle function. This angiogenic ECM protein initiates a...

Insufficient vascularization currently limits the size and complexity for all tissue engineering approaches. Additionally, increasing or re-initiating blood flow is the first step toward restoration of ischemic tissue homeostasis. However, no FDA-approved pro-angiogenic treatments exist, despite the many pre-clinical approaches that have been developed. The relatively small size of peptides giv...

Thrombospondin 1, the prototypical protein of the thrombospondin protein family, is a potent endogenous inhibitor of angiogenesis. Although the effects of the thrombospondin 1 on neovascularization have been well studied, little is known about the anti-angiogenic potency of other proteins or peptide fragments derived from the proteins in this family. Here we identify a set of 18 novel, anti-ang...

A shift of the angiogenic balance to the proangiogenic state, termed the "angiogenic switch," is a hallmark of cancer progression. Here we devise a strategy for identifying genetic participants of the angiogenic switch based on inverse regulation of genes in human endothelial cells in response to key endogenous pro- and antiangiogenic proteins. This approach reveals a global network pattern for...

Preeclampsia is a devastating multisystem syndrome and is a major cause of maternal, fetal and neonatal morbidity and mortality. Angiogenic factors contribute to the molecular mechanisms of preeclampsia and its main phenotypes such as hypertension and proteinuria. Very recently, novel anti-angiogenic proteins including soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), and...

Glioblastoma (GBM) is a highly aggressive primary brain tumor with dismal outcome for affected patients. Because of the significant neo-angiogenesis exhibited by GBMs, anti-angiogenic therapies have been intensively evaluated during the past years. Recent clinical studies were however disappointing, although a subpopulation of patients may benefit from such treatment. We have previously shown t...

PURPOSE Stromal vascularization is a frequent occurrence in herpes simplex keratitis (HSK) and carries a poor prognosis for penetrating keratoplasty. The pathogenesis may involve disruption of the normal equilibrium between angiogenic and anti-angiogenic factors in and around the cornea. Thrombospondin (TSP) 1 and 2 are multifunctional matricellular glycoproteins with potent anti-angiogenic pro...