Background: It has been suggested that inflammation might be implicated in the gestational diabetes mellitus (GDM) complications, including insulin resistance. The aims of the current study were to explore maternal circulating values of TNF-α, adiponectin and the adiponectin/TNF-α ratio in women with GDM compared with normal pregnancy and their relationships with metabolic syndrome ...

Objective(s): To observe and determine the effect and mechanism of psoralen on tumor necrosis factor-α (TNF-α)-induced muscle atrophy.Materials and Methods: Three sets of C2C12 cells, including blank control, TNF-α (10 or 20 ng/ml) treatment and a TNF-α (10 or 20 ng/ml) plus psoralen (80 μM) administration were investigated. Cell viabili...

background: periodontitis and rheumatoid arthritis (ra) share a number of clinical and pathologic features, one of which is the presence of the tumor necrosis factor alpha (tnf-α)-induced bone resorption that is involved in the pathogenesis of both. objectives: to investigate the effect of tnf-α blockade on periodontal conditions in patients with active ra. method: the periodontal statuses of 3...

introduction: daphne species has both pharmaceutical applications and anti tumor activity. it has been shown that the extract of daphne mucronata is effective in decreasing the size of breast adenocarcinoma in rats. we investigated the mechanism of action and the effects of the extract on tnf-a and tnf-a receptors on cultured human monocytes. material and methods: the breast tumors were induced...

introduction: the systemic and local content of inflammatory cytokines and chemokines play substantial roles in pathophysiology of arthritis. this study was purposed to verify the roles of synovial tnf-α, il-6 and fractalkine (fkn) in edema changes during different stages of complete freund’s adjuvant (cfa)-induced knee arthritis in rats. methods: 168 male wistar rats were divided in 7 groups a...

background: correlations between bone marrow, heart, kidney, liver, skin and lung transplant rejection or survival with human cytokine gene polymorphisms have been described. there are also reports about the role of cytokines and tumor necrosis factors-alpha (tnf-α) on corneal transplant in animal models. further studies are needed to clarify the role of cytokines in corneal allograft rejection...

background tnf-α is one of the most potent cytokines in proinflammatory reactions. results one hundred and twenty children with acute pyelonephritis were evaluated. urinary tnf-α/cr was 0.0051 ± 0.00083 pg/g creatinine. the authors found out a significant difference in urinary tnf-α/cr between patients who have normal and abnormal levels of urine leukocytes, urine protein, urine culture, erythr...

Background: Periodontitis and rheumatoid arthritis (RA) share a number of clinical and pathologic features, one of which is the presence of the tumor necrosis factor alpha (TNF-α)-induced bone resorption that is involved in the pathogenesis of both. Objectives: To investigate the effect of TNF-α blockade on periodontal conditions in patients with active RA. Method: The periodontal statuses of 3...