Protein synthesis (translation) stops at stop codons, codons not complemented by tRNA anticodons. tRNAs matching stops, antitermination (Ter) tRNAs, prevent translational termination, producing dysfunctional proteins. Genomes avoid tRNAs with anticodons whose complement (the anticodon of the 'antisense' tRNA) matches stops. This suggests that antisense tRNAs, which also form cloverleaves, are o...

Peptide Receptor Radionuclide Therapy (PRRT) for the treatment of neuroendocrine tumors may lead to kidney deterioration. This study aimed to evaluate the suitability of 99mTc-mercaptoacetyltriglycine (99mTc--MAG3) clearance for the early detection of PRRT-induced changes on tubular extraction (TE). TE rate (TER) was measured prior to 128 PRRT cycles (7.6±0.4 GBq 177Lu-octreotate/octreotide eac...

C o r r e s p o n d ê n c i a : J o r g e E l i a s N e t o • R u a A l a ô r d e Q u e i r o z , 1 1 5 / 1 0 1 2 9 0 5 0 0 0 0 – V i t ó r i a , E S E-mail: [email protected], [email protected] Recebido em 14/05/05 • Aceito em 08/12/05 A possibilidade de se adotar a postura ortostática é, sem dúvida, um marco na evolução da espécie humana, e tem motivado extensa pesquisa nas áreas fi siológi...

It is perhaps apt that Wirral, as one of its amenity-societies proclaims: "eighteen miles long and six to seven wide, is a miniature of England as a whole"?and that here such pioneering moves should have been made; not the earliest but well in the van. Naturally enough, it was at the "business end" of the peninsula, in Birkenhead, that the inaugural meeting of the Wirral Association for Mental ...

Telomerase reverse transcriptase (TERT) and telomerase RNA (TER) function together to create a uniquely specialized polymerase. Here we have described for the first time domains of bacterially expressed Tetrahymena TERT that interacted directly with TER in the absence of assembly chaperones. We used quantitative binding assays to define TER sequence requirements for recognition by the high affi...

The reaction of m-terphenyl amine (2,6-bis-(2,4,6-trimethylphenyl)aniline, m-Ter = m-terphenyl = 2,6-bis-(2,4,6-trimethylphenyl)) and ECl(3) (E = P, As) in the presence of different bases (Et(3)N, n-BuLi, LDA, DBU) and under different reaction conditions was studied. The reaction with excess Et(3)N yielded m-Ter-N(H)-AsCl(2) for E = As, while for E = P m-Ter-N(PCl(2))(2) was formed. m-Ter-N(H)-...

To search for heretofore unidentified DNA replication termination (Ter) sites on the Escherichia coli chromosome, we screened the entire Kohara lambda bacteriophage library using as probes the four known 22-bp Ter sequences. We found a Ter site, which we named TerE, located at 23.2 min on the linkage map. TerE inhibits only counterclockwise DNA replication. Macroscopically, five Ter sites are l...