BACKGROUND The possible role of leukotriene receptor antagonist (LTRA) therapy in the pathogenesis of Churg-Strauss syndrome (CSS) is uncertain. The aim was to examine the association between LTRA therapy and CSS in cases registered in the FDA Adverse Event Reporting System (AERS) database. METHODS All cases of suspected drug-induced CSS reported to the AERS database between November 1997 and...

The American College of Rheuma• tology that has suggested 6 criteria from which 4 are required for a diagnosis of CSS with 99.7% specificity and 85% sensitivity. The 6 criteria include: asthma, eosinophilia > 10%, paranasal sinusitis, vasculitis based on histology, and mononeuritis multiplex [4]. Vasculitis lesions of CSS on histological examination are not typically seen in biopsies and are no...

In a study of articles published in the Proceedings of the National Academy of Sciences, Gunther Eysenbach discovered a significant citation advantage for those articles made freely-available upon publication (Eysenbach 2006). While the author attempted to control for confounding factors that may have explained the citation differential, the study was unable to control for characteristics of th...

barrel vaults are attractive space structures that cover large area without intermediate supports. in this paper, the charged search system (css) optimization algorithm is employed for optimal design of barrel vaults. this method utilizes the governing laws of coulomb and gauss from electrostatics and the newtonian law of mechanics. the results demonstrate the efficiency of the discrete css alg...

INTRODUCTION Ishikawa and Jefferson are the two most commonly used systems used for the classification of cavernous sinus syndrome (CSS). However, relative utilities of these two classification systems have not been evaluated in detail in developing countries. In this study, we compared relative utilities of these two classification schemes in the evaluation of CSS. OBJECTIVE To compare the u...

Exhaled nitric oxide (eNO) is decreased by cigarette smoking. The hypothesis that oxides of nitrogen (NOX) in cigarette smoke solution (CSS) may exert a negative feedback mechanism upon NO release from epithelial (AEC, A549, and NHTBE) and basophilic cells (RBL-2H3) was tested in vitro. CSS inhibited both NO production and degranulation (measured as release of beta-hexosaminidase) in a dose-dep...