First-pass metabolism is a common cause of incomplete and variable absolute bioavailability for an orally dosed drug. The drug-metabolizing enzyme CYP3A4 is often implicated in this process, resulting, in some cases, in systemic exposures of less than 15% of the administered dose. By creating an elegant CYP3A4-transgenic mouse model, van Herwaarden et al. show in this issue of the JCI that firs...

The NFL and NCAA Football are multi-billion dollar industry. Despite this, the process of preparing to face an opponent is a relative anachronism. Coaches watch and take notes of their opponents' game footage the week before game day. When it comes time to call plays, they rely on their memory and instincts in order to call the proper play. A defense would be at a distinct advantage if their co...