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The present study was undertaken to evaluate the osteogenic effect of Cervi cornu pantotrichum (CCP) on bone marrow stromal cells (BMSCs) which showed differentiation towards the osteoblastic phenotype. Cells were exposed to different culture medium (dexamethasone group, CCPE group and control group). The activities of osteoblastic markers such as alkaline phosphatase (ALP), bone gla protein (B...
High grain production of corn (Zea mays L.) can be maintained by adding inorganic N fertilizer, and also by using crop rotations that include alfalfa (Medicago sativa L.), but the relative impact of these management practices on soil quality is uncertain. We examined the effects on soil of N fertilization rate (0, 90, 180, 270 kg ha, corn phase only) in four cropping systems: CC, continuous cor...
Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...
Organic cation transporter (OCT) 2, multidrug and toxin extrusion protein (MATE) 1, and MATE2K mediate the renal secretion of various cationic drugs and can serve as the loci of drug-drug interactions (DDI). To support the evaluation of cynomolgusmonkey as a surrogate model for studying human organic cation transporters, monkey genes were cloned and shown to have a high degree of amino acid seq...
Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...
Background : Mental health is a matter of controversy in psychiatry. Individuals' ability to coping with changes and stresses is one of the factors that may influence mental health. The goal of the present study was to assess psychological morbidly and coping strategies in freshman students of Shaheed Beheshti University of Medical Sciences in 2004. Methods: During this cross sectional study, 2...
While the presence of an inflammatory response in AD (Alzheimer’s disease) is well known, the data on inflammation are conflicting, suggesting that inflammation either attenuates pathology, exacerbates it or has no effect. Our goal was to more fully characterize the inflammatory response in APP (amyloid precursor protein) transgenic mice with and without disease progression. In addition, we hav...
Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...
The single underlying method of “averaging the wavelet functional over translates” yields first a new completeness criterion for orthonormal wavelet systems, and then a unified treatment of known results on characterization of wavelets on the Fourier transform side, on preservation of frame bounds by oversampling, and on the equivalence of affine and quasiaffine frames. The method applies to mu...
Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9). Results from clinical drug-drug interaction studies suggest that CYP3A4/5 mediate metabolism of amlodipine. However, attempts to identify a role of...
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