Anaplastic thyroid carcinoma is a rare but very aggressive tumor. Many factors that might influence the survival of patients have been suggested. The aim of our study was to determine which of the factors, known at the time of admission to the hospital, might predict survival of the patients with anaplastic thyroid carcinoma. Our aim was also to assess the relative importance of the factors and...

Activating point mutations of the BRAF gene have been recently reported in papillary thyroid carcinomas. In this study, we analyzed 320 thyroid tumors and six anaplastic carcinoma cell lines and detected BRAF mutations in 45 (38%) papillary carcinomas, two (13%) poorly-differentiated carcinomas, three (10%) anaplastic carcinomas, and five (83%) thyroid anaplastic carcinoma cell lines but not in...

We studied the urokinase-type plasminoceli activator (uPA) receptor (uPA-R) in normal and neoplastic human thyroid cells. It has recently been shown that cleaved forms of uPA-R display an extremely strong chemotactic activity. Normal human thyroid TAD-2 cells express the intact form of the uPA-R and a truncated form lacking the uPA-binding domain on their surface, in a similar manner to tumor t...

nal diagnosis.6 Differential diagnosis between an anaplastic hyroid carcinoma and a secondary tumor is often difficult. he presence of cervical adenopathies, advanced patient ge, and neoplastic history may suggest a metastatic tumor, ut a positive thyroglobulin test will provide definite diagosis of an anaplastic carcinoma.7 In the case reported, the atient’s age, the rapid growth of previously...

Being one of the most lethal human neoplasms and refractory to such conventional treatment as chemo- and radiotherapy, anaplastic thyroid carcinoma is a prime target for innovative therapy. p53 gene inactivation is a constant feature of this neoplasia. Therefore, we evaluated a therapeutic approach based on an E1B 55-kDa gene-defective adenovirus (ONYX-015) that replicates only in cells with im...

Anaplastic thyroid carcinoma is an aggressive form of cancer with no treatment. Angiogenesis inhibitors, such as TNP-470, a synthetic derivative of fumagillin, have been shown to reduce tumor size and increase survival in heterotopic animal models of thyroid cancer. Our goals were to determine the effect of TNP-470 on anaplastic thyroid cancer using an orthotopic murine model, to identify the m...

INTRODUCTION We report a case of treatment of anaplastic thyroid carcinoma spread over the trachea with mediastinal extension. METHODS Case report and review of the world literature concerning the treatment of anaplastic thyroid carcinoma are presented. DISCUSSION The role of surgery in treatment of anaplastic carcinoma remains controversial. Our case we underlined two questions: the approp...

Most cases of anaplastic thyroid carcinoma can be pathologically and often historically associated with the presence of low-grade (differentiated) cancer in the thyroid. That radiation therapy to the differentiated tumor plays an etiologic role in the transformation of a differentiated to an undifferentiated tumor has been suggested. If such therapy can be implicated, is there a difference in r...

Thyroid cancer is the most common malignancy in endocrine system, composed of four major types; papillary thyroid carcinoma, follicular thyroid carcinoma, anaplastic thyroid carcinoma, and medullary thyroid carcinoma. The incidence of thyroid cancer, especially differentiated thyroid cancer, is increasing in developed countries. Growing body of studies on molecular pathogenesis in thyroid cance...