Before quality control techniques and protocols can be applied to a laboratory procedure, the quality itself must be evaluated. This involves among other considerations an assessment of analytical accuracy. Some, but not all (and perhaps not even many), clinical laboratory analytical procedures can be considered accurate in the sense that every laboratory should get the same quantitative result...

Analytical procedure for determination of glyceroltriheptanoate (GTH) in processed animal by-products was developed. Samples of meat and bone meal were sieved through 1 mm sieve, extracted with petroleum ether, and cleaned up on amino bonded solid phase extraction cartridges. Extracts were analysed with a gas chromatograph combined with flame ionisation detector, on DB5 capillary column (30 m, ...

An uncontrolled used of antibiotics and sulphonamides is responsible for the presence of residues in beehive products and contributes to the problem of food safety. The optimisation of analytical methods for the detection of residues of antibacterial drugs (sulphonamides, SPs; tylosin, TL; streptomycin, ST) in honey was pursued and the methods applied to routine samples. ST was investigated by ...

The suitability of analytical protocol for determination of sulfonamides in honey was investigated. Sulfonamides were extracted from honey with acetate buffer, and cleaned up by solid phase extraction (SPE) procedure. The liquid chromatography (LC) separation was carried out on RP C18 column and sulfonamides were monitored with fluorescence detector, after pre-column derivatisation. Recoveries ...

In this Stimuli article, the USP Validation and Verification Expert Panel discusses how the modern concept of a lifecycle model, which is based on process validation and described in ICH guidelines Q8, Q9, and Q10, can be applied to analytical procedures. The Expert Panel proposes that the traditional approaches to validation, transfer, and verification should be integrated into the analytical ...

This work presents an automated analytical procedure for the photometric determination of reducing sugars in wines. The procedure is based on the reaction of reducing sugars with potassium hexacyanoferrate(III) in an alkaline medium, and was implemented employing a multicommuted flow analysis (MCFA) approach. Sample heating to promote the reaction was accomplished using a flow-batch device, whi...

abstract: An analytical method validation represents a complete investigation of the materials’ properties, following certain steps, being necessary for “proving the fit for purpose of an analytical method”. The validation procedure demonstrate that a defined validation protocol for an analytical method applied to a specified testing material and a defined concentration of the analyt – named an...