Transgenic mice over-expressing mutant human amyloid precursor protein (PDAPP mouse) develop several Alzheimer’s disease (AD)-like lesions including an age-related accumulation of amyloid-?-containing neuritic plaques. Although aged, heterozygous PDAPP mice also exhibit synaptic and glial cell changes, that is characteristic of AD pathology, no evidence of neurodegeneration has been observed. T...

the purpose of this study was to evaluate the changes in the serum concentrations of haptoglobin (hp), serum amyloid a (saa) and igg, iga in calves with diarrhea caused by rotavirus, coronavirus, escherichia coli f5 and eimeria species. the experiment was carried out on 40 diarrhoeic and 10 non-diarrhoeic calves (group c). a total of 13 calves were infected with rotavirus or coronavirus (group ...

Platelet aggregation beta amyloid main causes inflammation of neurons in Alzheimer’s disease. In fact, creating this inflammation due to inappropriate actions in blood brain barrier (BBB) and astrocyte and microglia during the last century that studies conducted in this case nothing has been found. The only thing that can be done to prevent and reduce pro-inflammatory factors such as cyto...

Alzheimer’s disease (AD) is a neuroinflammatory based pathologic state in which β-amyloid aggregates are a major devastating agents. In this study, a series of 2-hydroxyiminoethanones were synthesized and evaluated as anti-inflammatory in carrageenan and formalin tests and inhibitors of β-amyloid aggregation. Compounds 1-10b were synthesized through a two-step reaction. Results: Compounds 1-5b ...

familial amyloid polyneuropathy (fap) type iv (finnish) is a rare clinical entity with challenging neuropathy and cosmetic deficits. amyloidosis can affect peripheral sensory, motor, or autonomic nerves. nerve lesions are induced by deposits of amyloid fibrils and treatment approaches for neuropathy are challenging. involvement of cranial nerves and atrophy in facial muscles is a real concern i...

Visual interpretation is considered the gold standard for amyloid scans in clinical practice. However, dichotomous classification of deposition by visual reading always results bias due to rater experience. Therefore, there a need more lenient and flexible amyloid-equivocal A total 461 participants were included this study. Amyloid glucose positron-emission tomography was performed, neuropsycho...

platelet aggregation beta amyloid main causes inflammation of neurons in alzheimer’s disease. in fact, creating this inflammation due to inappropriate actions in blood brain barrier (bbb) and astrocyte and microglia during the last century that studies conducted in this case nothing has been found. the only thing that can be done to prevent and reduce pro-inflammatory factors such as cytokines ...