Acute ammonia toxicity in vertebrates is thought to be characterized by a cascade of deleterious events resembling those associated with anoxic/ischemic injury in the central nervous system. A key event is the over-stimulation of neuronal N-methyl-D-aspartate (NMDA) receptors, which leads to excitotoxic cell death. The similarity between the responses to acute ammonia toxicity and anoxia sugges...

Aquaporin (AQP)8-facilitated transport of NH(3) has been suggested recently by increased NH(3) permeability in Xenopus oocytes and yeast expressing human or rat AQP8. We tested the proposed roles of AQP8-facilitated NH(3) transport in mammalian physiology by comparative phenotype studies in wild-type vs. AQP8-null mice. AQP8-facilitated NH(3) transport was confirmed in mammalian cell cultures e...

High concentrations of nitrogen compounds, such as ammonia observed in the petrochemical industry, are the major environmental pollutants. Therefore, effective and inexpensive methods are needed for its treatment. Biological treatment of various pollutants is a low cost and biocompatible replacement for current physico-chemical systems. The use of aquatic plants is an effective way to absorb th...

Ambient pH regulates the expression of virulence genes of Metarhizium anisopliae, but it was unknown if M. anisopliae can regulate ambient pH. Mutants of M. anisopliae altered in production of oxalic acid were evaluated for the interrelationship of ambient pH, buffering capacity added to media, growth, and generation of extracellular proteases and ammonia. Wild-type and acid-overproducing mutan...

HisH–hisF is a multidomain globular protein complex; hisH is a class I glutamine amidotransferase that hydrolyzes glutamine to form ammonia, and hisF is a ( )8 barrel cyclase that completes the ring formation of imidizole glycerol phosphate synthase. Together, hisH and hisF form a glutamine amidotransferase that carries out the fifth step of the histidine biosynthetic pathway. Recently, it has ...

this study was accomplished to examine the efficiency of natural zeolite in preventing acute toxicity of total ammonia to huso huso. the study was performed using water static method in 96 hours. fish averaged 46 ? 5 g in weight and 22 ? 4 cm in total length were exposed to four different concentrations (15, 30, 50, 75 mgl-1) of ammonia and a group was considered as control. under stable condit...

how to cite this article: khalessi n, khosravi n, mirjafari m, afsharkhas l. plasma ammonia levels in newborns with asphyxia. iran j child neurol. winter 2016; 10(1):42-46. abstract objective perinatal asphyxia may result in hypoxic damage in various body organs, especially in the central nervous system. it could induce cascade of biochemical events leading to the cell death and metabolic chang...

in this work, reactive absorption of gases in aqueous electrolyte solutions has been investigated resulting in the development of a procedure in order to calculate the concentrations of ionic and molecular species in the liquid phase. two duplicate experiments were conducted to investigate simultaneous reactive absorption of ammonia and carbon dioxide in partially carbonated ammonia solutions. ...

The disordered-molecular-alloy phase (DMA) of ammonia hydrates [J. S. Loveday and R. J. Nelmes, Phys. Rev. Lett. 83, 4329 (1999)] is unique in that it has substitutional disorder of ammonia and water over the molecular sites of a body centred cubic lattice. Whilst this structure has been observed in ammonia di- and mono-hydrate compositions, it has not been conclusively observed in the ammonia ...