BACKGROUND Apnea is associated with prostaglandin E1 infusion (PGE1) used in the palliation of ductal-dependent congenital heart lesions. HYPOTHESIS Aminophylline is a central respiratory stimulant and will decrease the incidence of PGE1-associated apnea and the need for intubation for apnea in infants with ductal-dependent congenital heart disease. METHODS Informed consent was obtained for...

Introdution: Acute renal failure is a common complication in the brain injury patients. Released adenosine in injury can reduce renal glomerular filtration. Aminophylline is an inhibitor of releasing adenosine. So, this study aimed to evaluate the effect of intravenous aminophylline in renal function of brain-injured patients with acute renal failure admitted to the intensive care unit. Method...

The Department of Health estimates that asthma including 10 major causes morbidity and mortality in the hospital. Asthma is a chronic respiratory disease becoming serious health problem many countries around world. Drugs used treatment exacerbations salbutamol aminophylline. such as aminophylline can cause ADR (Adverse Drug Reaction) form tremor with sign involuntary shaking part hand. This res...

OBJECTIVES To determine whether children with severe acute asthma treated with large doses of inhaled salbutamol, inhaled ipratropium, and intravenous steroids are conferred any further benefits by the addition of aminophylline given intravenously. STUDY DESIGN Randomised, double blind, placebo controlled trial of 163 children admitted to hospital with asthma who were unresponsive to nebulise...

In patients with acute exacerbations of asthma, the intravenous administration of bronchodilators, such as salbutamol, entails the potential risk of worsening pulmonary gas exchange, despite an amelioration of airflow obstruction. The present study was designed to investigate the effect of intravenous aminophylline on pulmonary gas exchange in patients hospitalized with a severe exacerbation of...

background: the objective of this study is to assess the safety and preventative effects of aminophylline on the incidence of chronic lung disease (cld) in very premature infants. methods: this was a long follow‑up randomized clinical trial. the prophylactic effect of aminophylline on the incidence of cld was investigated in very premature infants. the study group received aminophylline for the...

OBJECTIVE To determine if aminophylline administration is associated with improved creatinine clearance and greater urine output in children with acute kidney injury in the cardiovascular ICU. DESIGN Single-center retrospective cohort study. SETTING Pediatric cardiovascular ICU, university-affiliated children's hospital. PATIENTS Children with congenital or acquired heart disease in the c...

Background: Methylxanthines like theophylline are re-emerging as effective adjuncts in the treatment of obstructive airway disease and several newer mechanisms have been proposed. In view of its effectiveness, pharmacoeconomic viability, and easy availability, it could rationalize the drug treatment in bronchial asthma and chronic obstructive pulmonary disorders (COPD) – but its narrow therapeu...

Male albino rats weighing between 150-225 gm fasted over night but freed having water ad libitum were used to assess the diuretic efficacy of intramuscular aminophylline and frusemide separately and concurrently after intraperitoneal 10 ml of distilled water loading. The normal rate of diuretic weight loss was less augmented by aminophylline and more augmented by frusemide. The diuretic respons...

BACKGROUND Adenosine cardiovascular magnetic resonance (CMR) can accurately quantify myocardial perfusion reserve. While regadenoson is increasingly employed due to ease of use, imaging protocols have not been standardized. We sought to determine the optimal regadenoson CMR protocol for quantifying myocardial perfusion reserve index (MPRi) - more specifically, whether regadenoson stress imaging...