Submit Manuscript | http://medcraveonline.com classes of pyrimidines. The pharmaceutical importance of these compounds lies on the fact that they can be effectively used as analgesics, anti-inflammatory, anticonvulsant, insecticidal, herbicidal, antitubercular, anticancer and antidiabetic agents [4-6]. Also, the pyrimidine and aminopyrimidine structures are frequently-occurring motifs in commer...

The association of magnetite microparticles with bi-functional amino-sulfonate polymer (obtained by condensation guanidine and amino hydroxynaphthalene sulfonic acid, mediated formaldehyde) allows synthesizing a magnetic composite sorbent (M−GANS). bearing both amine sulfonate groups is efficient for uranyl sorption at pH 4–5. isotherms are successfully fitted the Temkin equation, while kinetic...

Sialic acid is the active site of neuraminidase protein, eventually it cleaves form its substrate via sialsyl cation intermediate and proliferates viral infection to other cells. On account weak binding affinity between receptor, communicates cells leads mortality humans. DANA first sialidase inhibitor formed by dehydration C2 hydroxyl group sialic acid. The replacement at C4 position an amino ...

We develop a model for the reversible denaturation of proteins and for the effects of single-site mutations on the denatured states. The model is based on short chains of sequences of H (hydrophobic) and P (other) monomers configured as self-avoiding walks on the two-dimensional square lattice. The N (native) state is defined as the unique conformation of lowest contact energy, whereas the D (d...

Contributions of tyrosyl residues to trypsinand chymotrypsin-inhibitory activities in two homologous proteinase inhibitors were investigated by modifying them with N-acetylimidazole under various conditions. In Bowman-Birk soybean proteinase inhibitor, Tyr 55, immediately following the antichymotryptic site, Leu 53-Ser 54, is relatively inaccessible to N-acetylimidazole and can only be acetylat...

The title compound, CH(7)N(4) (+)·C(4)H(5)O(4) (-), is a molecular salt containing discrete amino-guanidinium and succinate ions. The amino-guanidinium cation is nearly planar, with a maximum deviation of 0.035 (1) Å. The dihedral angle between the amino-guanidinium cation and the succinate anion is 3.35 (6)°. The crystal packing exhibits inter-molecular N-H⋯O and O-H⋯·O hydrogen bonds.

Well-grown single crystals of NaCN3H4(CN3H5)2 were synthesized from guanidine and sodium hydride. The new compound crystallizes in the monoclinic space group P21/n (no. 14) with Z = 4 and a = 6.2007(4), b = 9.6261(8), c = 15.7630(11) Å and β = 93.783(3)◦ at 293 K. The asymmetric unit comprises two sodium cations on special positions, one guanidinate anion and two symmetry-independent guanidine ...

Thyroglobulin obtained from guinea pigs was examined by Na dodecyl-SO4-polyacrylamide gel electrophoresis after reduction and alkylation. In contrast to thyroglobulin from other mammalian sources, only three groups of polypeptide chains accounted for 95% or more of the protein. Determinations of the molecular weights of these purified proteins by equilibrium centrifugation in 6 M guanidine HCl ...