In this work, sub-50 nm pegylated mesoporous silica nanoparticles prepared with hydrothermal treatment are shown to have long-term stability in various media at both room and physiological temperature. Compared to bare mesoporous silica nanoparticles, the highly pegylated mesoporous silica nanoparticles show significantly improved biocompatibility and decreased macrophage uptake, making these n...

The new magnetic amine-functionalized graphene oxide (Fe3O4-GO-NH2) nanocatalyst was prepared through the reaction of 3-aminopropyltriethoxysilane (APTES) with magnetic graphene oxide (Fe3O4-GO). It was characterized by XRD, TEM, SEM, FT-IR and EDX techniques. The intrinsic carboxylic acids on the edges of Fe3O4-GO alo...

Amine-functionalized mesoporous SBA-15 silica loaded with bovine serum albumin (BSA) has been successfully encapsulated with a thin layer coating of poly(acrylic acid) PAA, with the entrapped BSA being released from the PAA-encapsulated SBA-15 at the higher pH value of 7.4 rather than at the lower pH value of 1.2. This novel drug delivery system has a potential application in the release of pro...

Objective(s): Study and development of antifouling nanosystem for conjugation of drugs were attracting great attention in recent years. The present study aimed to develop novel curcumin-loaded silica nanoparticles containing zwitterionic coating as an antifouling system to provide protein corona free nanoformulations for curcumin. Materials and Methods: Silica nanoparticles were prepared ...

Mesoporous silica thin films and nanoparticles prepared by surfactant-templated sol–gel techniques are versatile substrates that can be easily erivatized with active molecules to create functional materials. By exploiting the chemical and physical differences that exist in different regions f the mesostructure, active molecules can be deliberately placed using one-pot techniques, or they can be...

We present a novel therapeutic nanoplatform based on mesoporous silica nanoparticles encapsulating ferulic acid/gemcitabine and functionalized with anti-GPC1 antibodies to target human pancreatic cancer (PANC-1) cells.

Functionalized mesoporous silica has applications in separations science, catalysis, and sensors. In this work, we studied the fundamental interactions of trivalent cations with functionalized mesoporous silica. We contacted trivalent cations of varying ionic radii with N-[5-(trimethoxysilyl)-2-aza-1-oxopentyl]caprolactam functionalized mesoporous silica with the aim of probing the binding mech...

The present study deals with the synthesis andfunctionalization of mesoporous silica nanoparticles as drug delivery platforms. SBA-15 nanorods with high surface area (1010 m2g-1) were functionalized by post grafting method using 3-mercaptopropyl trimethoxysilane (MPTS). The parent and thiol-functionalized SBA-15 nanorods were used as nanocarriers for an anticancer drug (gemcitabine). The charac...

Host-Guest chemistry based on mesoporous silica materials has attracted increasing attention in the past two decades. Potential applications for these functionalized materials are in the fields of controlled drug delivery, catalysis, separation or encapsulation of functional biomolecules. The present work is focused on the synthesis of nanosized, mesoporous drug delivery devices, which are able...