The aim of this study was to investigate the effect of local administration of odanacatib (ODN) on orthodontic root resorption and the status of alveolar bone metabolism in rat molars. All specimens were scanned using microcomputed tomography and then the raw images were reconstructed. The total volume of the root resorption craters of the 60 g-NS (normal saline) group was higher than in the 60...

Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development and osteoclast function. Therefore, RANKL plays a critical role in periodontal bone resorption. I...

Abstract Bisphosphonates remain the most used and effective drugs for treatment of systemic bone diseases followed by resorption. Although their side effects in a form alveolar osteonecrosis have been reported, bisphosphonates potential being common oral resorption such as peri-implantitis, periapical lesions, periodontitis. The aim this article was to review recent research regarding use field...

background: alveolar ridge preservation could be performed immediately following tooth extraction to limit dimensional changes of alveolar process due to bone resorption. the aim of this study was to compare the clinical and histologic outcomes of socket preservation using two different graft materials; deproteinized bovine bone mineral (dbbm) and demineralized freeze‑dried bone allograft (dfdb...

Progressive alveolar bone resorption after tooth extraction may lead to surgical and prosthetic-driven difficulties, especially when deciding to use a dental implant to replace the extracted tooth. This case report discusses an irreparable lower left second premolar tooth with a periodontal lesion on the buccal side. A preservative tooth extraction was performed. Then, the socket was grafted wi...

Background: Tooth extraction is a common dentistry procedure followed by alveolar bone resorption. Trauma that occurs in tooth will induce exaggerating inflammatory process, leads to increased Bone resorption can be minimized administering combination of Nigella sativa extract and bovine graft. The material expected increase the woven area formation speed up remodeling process. Purpose: To dete...

PGE(2) acts as a potent stimulator of bone resorption in several disorders including osteoarthritis and periodontitis. Three PGE synthases (PGES) were isolated for PGE(2) production, but which PGES has the major role in inflammatory bone resorption is still unclear. In this study, we examined the role of PGE(2) in LPS-induced bone resorption using membrane-bound PGES (mPGES)-1-deficient mice (m...

Osteoporosis after menopause is a growing public health concern that impacts bone health. It characterised by weak and fracture prone bones. Women are nearly four times likely as men to be affected. The goal improve proper prosthodontic therapy so residual ridge resorption reduced. main alveolar tooth loss or movement, which osteoporotic women three more sensitive than those without condition. ...