Objective: This study aimed to investigate the combined effects of caffeine and Alpha Lipoic Acid (ALA) on oxidative stress, due chronic hyperglycemia, in a model diabetic rats induced with streptozotocin (STZ) (in silico vivo approaches). Material Methods: In investigated interaction between ALA against insulin receptors enzymes Glutathione Peroksidase-1 (GPx-1), molecular docking. Male, Wista...

introduction: this study evaluated the effects of pretreatments with melatonin (mt), and alpha lipoic acid (ala) on lopinavir/ritonavir (lpv/r) -induced serum levels of creatinine (cr), urea (u), uric acid (ua) and kidney levels of malondialdehyde (mda), superoxide dismutase (sod), glutathione (gsh) and catalase (cat) in male albino rats. effects of treatments with mt and ala were also evaluate...

α-Lipoic acid and L-carnosine are powerful antioxidants and are often used as a health supplement and as an ergogenic aid. The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks. Four treatment groups received diets containing regular rat chow di...

Abbreviations: DGC, dystrophin glycoprotein complex; DAPC, dystrophin associated protein complex; β-DG, Beta-dystroglycan; ALA, Alpha-lipoic acid; L-Car, L-carnitine; CK, creatine kinase; TBARS, thiobarbituric acid reactions; SOD, superoxide dismutase; CAT, catalase; GPx, glutathione peroxidase; MyHC, myosin heavy chain; HO-1, Heme oxygenase-1; NF-κB, nuclear factor-κB; MMP, Matrix Metalloprote...

Potassium permanganate (KMnO4) and oleic acid (OA) were purchased from Alfa Aesar. Glutathione (GSH), 3-(4,5-dimethylthialzol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), alpha lipoic acid (ALA), buthionine sulfoximine (BS) and N-ethylmaleimide (NEM) were purchased from Sigma-Aldrich. Doxorubicin hydrochloride (DOX) was purchased from Dingguo reagent company (Beijing, China). All buffers were p...

1. Sardella A. An up-to-date view on burning mouth syndrome. Minerva Stomatol. 2007;56:327-40. 2. Zakrzewska JM, Forssell H, Glenny M. Interventions for the treatment of burning mouth syndrome. Cochrane Database Syst Rev. 2005;25:CD002779. 3. Mínguez Serra MP, Salort Llorca C, Silvestre Donat FJ. Pharmacological treatment of burning mouth syndrome: A review and update. Med Oral Patol Oral Cir B...

OBJECTIVES To determine whether supplementation with alpha-lipoic acid (ALA), a glutathione-replenishing disulfide, modulates whole blood total glutathione (GSH + GSSG) levels and improves lymphocyte function in human immunodeficiency virus (HIV)-infected subjects with history of unresponsiveness to highly active antiretroviral treatment (HAART). DESIGN AND SETTING Randomized, double-blinded,...

BACKGROUND It has been generally accepted that being overweight or obese is a risk factor for several types of cancers, including breast, thyroid, colon, pancreatic and liver. In fact, people who are obese have more fat tissues that can produce hormones, such as insulin or estrogen, which may cause cancer cells to grow. Alpha lipoic acid (ALA) is anorganosulfur compound derived from octanoic ac...

Background: Long term administration of antiepileptic drug phenytoin is reported to cause behavioral abnormalities mediated via oxidative stress. The effect of an antioxidant alpha lipoic acid (ALA) against phenytoin induced behavioral abnormalities was investigated. Methods: The study was carried out in albino wistar rats. The rats were divided into five groups of six animals each. Group 1 rec...

The use of lopinavir/ritonavir (LPV/r) could be associated with testicular toxicity as a limiting factor. The present study evaluated the effects of melatonin (MT) and alpha lipoic (ALA) acid on LPV/r–induced testicular toxicity in male albino rats. Eighty five male albino rats used for this study were randomized into 6 groups (A-F). Rats in group A1 and A2 served as placebo and solvent control...