Alpha thalassemia is a genetic disease characterized by insufficient expression or definite absence of the α-globin chain. Three large deletions (thal-1; 26.5 kb MedII, 20.5 and 17.4 MedI) two small (thal-2; 4.2 3.7 kb) have been in our country. In addition, different PolyA mutations (PA1: AATAAA>AATAAG PA2: AATAAA>AATGA) on α2-globin gene (αα/αPAα), 5nt deletion (αα/α5ntα), unstable Hb v...

Hemoglobin is a tetrameric oxygen transport protein in animal bodies. However, there is a paucity of information regarding differences between alpha and beta subunits of hemoglobin in terms of oxygen affinity. The sequential model of Koshland, Nemthy and Filmer (KNF model) has attributed similar affinities to both alpha and beta subunits. The main purpose of the present study is to construct a ...

Yau [Math. Ann. 207 (1974), pp. 269–270] proved that: There is no non-trivial continuous concave function on a complete manifold with finite volume. We prove analogue theorems for several metric spaces, including Alexandrov spaces curvature bounded below/above, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="upper C Superscript alpha...

Abstract We compare the regularity of boundary a convex set with value its Finslerian volume entropy. The main result states that entropy two-dimensional domain whose associated curvature measure is Ahlfors $$\alpha $$ α -regular $$\frac{2\alpha }{\alpha +1}$$ 2 </mml:m...

Alpha thalassemia (α-thal) is relatively common worldwide. Most carriers are defective in either one or two alpha globin genes out of four functional ones, with deletions being more common than point mutations. The hematologic features are very important for the selection of the appropriate molecular tests while determining the genotype. The aim of this study was to compare hematologic features...

Let M be a connected compact Riemannian manifold possibly with boundary ∂M, let V ∈ C2(M) such that μ(dx) := eV (x)dx is probability measure, where dx the volume and L =Δ +∇V. As continuation to Wang Zhu (2019) convergence in quadratic Wasserstein distance \(\mathbb {W}_{2}\) studied for empirical measures of L-diffusion process (with reflecting if ∂M≠∅), this paper presents exact rate subordin...

A bstract We present, for the first time, complete off-shell 4 D, $$ \mathcal{N} N = 2 superfield actions any free massless integer spin s ≥ fields, using harmonic super-space approach. The relevant gauge supermultiplet is accommodated by two real analytic bosonic superfields {h}_{\alpha \left(s-1\right)\dot{...

Alpha (Α) thalassaemia is the most common inherited disorder in Malaysia. The clinical severity is dependant on the number of Α genes involved. Full blood count (FBC) and haemoglobin (Hb) analysis using either gel electrophoresis, high performance liquid chromatography (HPLC) or capillary zone electrophoresis (CE) are unable to detect definitively alpha thalassaemia carriers. Definitive diagnos...

Due to the alpha-particle beam interaction with tritium, two-dimensional spectra of tt, t3He, and dd coincidences are obtained using particle-decay spectroscopy from three-particle 3H(α,tt)p, 3H(α,t 3He)n, 3H(α,td)d reactions (Eα = 67.2 MeV). Excitation energies energy widths for seven excited 4He states, as well ratio their different decay modes, namely t + p, n 3He, d d, by Monte Carlo method.

Alpha thalassaemia is highly prevalent in the plural society of Malaysia and is a public health problem. Haematological and molecular data from 5016 unrelated patients referred from various hospitals to the Institute for Medical Research for α thalassaemia screening from 2007 to 2010 were retrieved. The aims of this retrospective analysis were to describe the distribution of various alpha thala...