The significance of an immune response in complications of bone allograft procedures is not well understood. This study evaluates the immunological reaction to bone allografts in either cortical or cancellous form. Serological responses from osteoarthritis (OA) patients and normal individuals to soluble proteins extracted from allografts were assessed using Western blotting and ELISA techniques...

Skin but not vascularized cardiac allografts from B6.H-2bm12 mice are acutely rejected by C57BL/6 recipients in response to the single class II MHC disparity. The underlying mechanisms preventing acute rejection of B6.H-2bm12 heart allografts by C57BL/6 recipients were investigated. B6.H-2bm12 heart allografts induced low levels of alloreactive effector T cell priming in C57BL/6 recipients, and...

The H-2 isoantigenicity of murine tissues was unaffected by the intraperitoneal growth of the Ehrlich ascites tumor, as shown by their normal capacity to absorb H-2 isohemagglutinins. Skin grafts from Ehrlich ascites tumor-bearing C57BL mice had a longer survival in RIII mice than grafts from nor mal donors. First-set allografts from tumor-bearing donors effectively immunized the hosts against ...

Experiments were carried out to investigate rat aortic allograft calcification using valved abdominal aortic allografts. Results indicated that this was a potentially useful model for investigating fresh allograft calcification, as well as mineralization of glutaraldehyde-crosslinked valved allografts. Valve cusp results, however, were not comparable to those noted in large animal or human stud...

January 2009 E25 U se of allografts for cruciate ligament reconstruction in the knee is increasing in popularity, but graft selection remains controversial. There is a dearth of information on long-term outcomes of allografts for cruciate reconstruction. Allografts are particularly useful in posterior cruciate ligament (PCL) reconstructive surgery because this procedure is often performed with ...

Different bone allografts (pasteurized, autoclaved, and frozen) were compared based on their osteoinductive properties. Our primary purpose was to examine the biologic qualities of pasteurized allografts, as pasteurization inactivates most viruses transmitted by transplantation. Frozen, pasteurized, and autoclaved allografts were packed into a standard defect of rabbit ulna. The animals were sa...

Musculoskeletal allografts are now commonly used. To decrease the potential risks of transmission of pathogenic bacteria, fungi, or viruses to the transplant recipients, certain issues regarding the management of patients who receive contaminated allografts need to be addressed. We aimed to clarify the incidence and extent of disease transmission from allografts by analyzing the allografting pr...

Chronic airway rejection, characterized by lymphocytic bronchitis, epithelial cell damage, and obliterative bronchiolitis (OB), limits long-term survival after lung transplantation. The transcription factor early growth response gene-1 (Egr-1) induces diverse inflammatory mediators, some involved in OB pathogenesis. An orthotopic mouse tracheal transplant model was used to determine whether Egr...

We investigated the fate of the cadaver renal transplant done with cyclosporine and prednisone immunosuppression into a recipient who had suffered the loss of at least two prior allografts. Nineteen cadaver renal allografts were transplanted into 18 recipients. All 18 recipients had previously rejected at least two prior allografts. One of these rejected an allograft done at our institution wit...

BACKGROUND Few medium-term or long-term reports on meniscal allograft transplantations are available. In this study, we present the results of a survival analysis of the clinical outcomes of our first 100 procedures involving transplantation of viable medial and lateral meniscal allografts performed in ninety-six patients. METHODS Thirty-nine medial and sixty-one lateral meniscal allografts w...