The specific 1,3 dipolar Hüisgen cycloaddition reaction known as 'click-reaction' between azide and alkyne groups is employed for the synthesis of peptide-oligonucleotide conjugates. The peptide nucleic acids (PNA)/DNA and peptides may be appended either by azide or alkyne groups. The cycloaddition reaction between the azide and alkyne appended substrates allows the synthesis of the desired con...

As a new model of chemical assay-guided natural product isolation, an effective chemodosimetric assay system was devised. Our chemical assay system features a fluorogenic chemodosimeter immobilized on a solid support, which offers advantages in identifying the desired compounds in complex natural product mixtures. To isolate only compounds with the target functional groups, the click chemistry ...

As a new model of chemical assay-guided natural product isolation, an effective chemodosimetric assay system was devised. Our chemical assay system features a fluorogenic chemodosimeter immobilized on a solid support, which offers advantages in identifying the desired compounds in complex natural product mixtures. To isolate only compounds with the target functional groups, the click chemistry ...

The merging of site-specific incorporation of small bioorthogonal functional groups into proteins via amber codon suppression with bioorthogonal chemistry has created exciting opportunities to extend the power of organic reactions to living systems. Here we show that a new alkyne amino acid can be site-selectively incorporated into mammalian proteins via a known orthogonal pyrrolysyl-tRNA synth...

We analyzed the ligand electronic effect in a gold(I)-catalyzed intramolecular alkyne hydroamination, through a DFT and charge-displacement function (CDF) study. We found that, in the presence of π-electron conjugation between the alkyne and the nucleophilic functionality, electron poor ligands modify the coordination mode and the geometric parameters of the substrate in such a way that, contra...

The azidation of glutathione (GSH)-functionalized ultrasmall gold nanoparticles (2 nm) by the azide transfer reagent imidazole-1-sulfonyl hydrogen sulfate leads to azide-terminated with high yield. A subsequent copper-catalyzed azide-alkyne cycloaddition (CuAAC), i. e. a click reaction, covalently functionalized nanoparticles. This was demonstrated two alkyne-functionalized dyes, FAM-alkyne and...

In the presence of gold(I)-phosphine catalysts, alkenyl- and arylsilanes undergo intramolecular cyclisation reactions onto appendant alkyne moieties to afford 1-silaindene derivatives. The reaction pathways vary depending on the substituent on silicon.

Correction for 'Emerging approaches for the synthesis of triazoles: beyond metal-catalyzed and strain-promoted azide-alkyne cycloaddition' by Carolina G. S. Lima et al., Chem. Commun., 2015, 51, 10784-10796.

A concise two-step click/ESA-CF process has been developed to prepare a kyklo-telechelic poly(tetrahydrofuran), poly(THF), having three functional groups at the constant intervals. Thus, a key linear precursor (I), having N-phenylpyrrolidinium salt groups at the chain ends and having two hydroxyl groups at the prescribed inner positions, has been prepared through the alkyne−azide addition (clic...

The direct synthesis of nitrile from N2 under mild conditions is great importance and has attracted much interest. Herein, we report a conversion into via nitrile–alkyne cross-metathesis (NACM) process involving N2-derived Mo nitride. Treatment the nitride with alkyne in presence KOTf afforded an alkyne-coordinated nitride, which was then transformed MoV carbyne corresponding upon 1 e? oxidatio...