Total alkaloid extract of the leaves of Siparuna sessiliflora was analyzed by gas chromatography coupled to a mass detector (GC-MS) and nuclear magnetic resonance (NMR). Ushinsunine and 4'-O-methyl-Nmethylcoclaurine, were identified as major compounds, along with liriodenine, corydine, Nmethyllaurotetanine, boldine, N-methylcoridaldine, nornuciferine, stepholidine and nantenine. The alkaloids u...

Indigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/microsome assays using TA100, TA98, TA102 and TA97a strains. The methanolic extract of I. truxillensis showed mutagen...

background and objectives: many members of the amaryllidaceae are regarded as toxic. the toxic constituents that occur in the whole family are referred to as the amaryllidaceae alkaloids. the main aim of this study was the identification of alkaloid compounds from galanthus transcaucasicus fomin, a medicinal plant from amaryllidaceae. methods: planar and column chromatography techniques were us...

In the present study, we investigate the effects of three different Mitragyna speciosa extracts, namely methanolic, aqueous and total alkaloid extracts, on glutathione transferase-specific activity in male Sprague Dawley rat liver cytosol in vitro and in vivo. In the in vitro study, the effect of Mitragyna speciosa extracts (0.01 to 750 microg/mL) against the specific activity of glutathione tr...

Berberis aetnensis C. Presl (Berberidaceae) is a bushy-spiny shrub common on Mount Etna (Sicily). We demonstrated that the alkaloid extract of roots of B. aetnensis C. Presl contains prevalently berberine and berbamine, possesses antimicrobial properties, and was able to counteract the upregulation evoked by glutamate of tissue transglutaminase in primary rat astroglial cell cultures. Until now...

Berberis microphylla is a native plant that grows in Patagonia and is commonly used by aboriginal ethnic groups in traditional medicine as an antiseptic for different diseases. The present study evaluated the antibacterial and synergistic activity of alkaloid extracts of B. microphylla leaves, stems and roots used either individually or in combination with antibiotics against Gram-positive and ...

Objective: The aim of the present work was to assess the total phenolic content (TPC), total flavonoid content (TFC), and total alkaloid content (TAC) of crude hydro-methanolic seed extract of Abrus precatorius L. which is one of the beautiful seed bearing plant belonging to family Fabaceae and used extensively in many Ayurvedic preparations with significant therapeutic significance. Methods: T...

Seven new indole alkaloids (1-7) comprising four vobasine, two tacaman, and one corynanthe-tryptamine bisindole alkaloid were isolated from the stem-bark extract of a Malayan Tabernaemontana. Two of the new vobasine alkaloids (1, 3), as well as 16-epivobasine (15) and 16-epivobasenal (17), showed appreciable cytotoxicity toward KB cells (IC50 ca. 5 μg/mL). The structure of the known Tabernaemon...

The experiments were purposed to investigate the effect of chitosan and yeast extract on Stemona alkaloid production in Stemona sp. culture. Both elicitors enhanced Stemona alkaloid production over the control. Treatment with chitosan at a concentration of 25 mg/L for 1 week resulted in the highest production of Stemona alkaloids. It was found that 1', 2'-didehydrostemofoline and stemofoline pr...

In the present work, the antinociceptive action was assayed in several experimental models in mice: writhing, formalin and hot plate tests. The crude alkaloid fraction (25, 50, 100 mg/ ???????? ???????? ?????? ???? ?????????????????????????????? ?????????????? ?????????????????????????? ???????????????? ???????? ???????????????????????? ?????? ?????????????? ?????????? intraperitoneal inject...