Using a triple-lumen constant perfusion system, the following observations were made in normal subjects. First, chloride, bicarbonate, and sodium were found to exhibit net movement across ileal mucosa against electrochemical gradients. Second, during perfusion with a balanced electrolyte solution simulating plasma, the ileum generally absorbed, but sometimes secreted fluid. A reciprocal net mov...

say. J Clin Endocrinol Metab 27: 973-990, 1967 16. 13. Brecher G, Cronkite EP: Morphology and enumeration of human blood platelets. J Appl Physiol 3: 365-377, 1950 14. Baumgartner HR: Eine neue Methode zur Erzengung von Thromben 17. durch gesielte uberdehnung der Gefasswant. Z Ges Exp Med 137: 227-249, 1963 15. Stemerman MB, Spaet TH, Pitlick F, Cintron J, Lejnieks I, Tiell ML: 18. The pattern ...

Alkaptonuria is a rare autosomal recessive disorder of metabolism caused by deficiency of homogentisic acid oxidase and resulting in accumulation of homogentisic acid in collagenous structures. This causes the classic clinical triad: (1) homogentisic aciduria (urine blackens on standing when oxidized or alkalinized); (2) eumelanin-like pigmentation of skin, sclera, cartilages, etc and (3) degen...

To study correlations between the concentrations, in serum, of amitriptyline and its most important metabolites with clinical response in patients, we developed a "high-performance" liquid-chromatographic method for routine determination of amitriptyline, nortriptyline, total 10-hydroxy-amitriptyline, desmethylnortriptyline, and E(trans)- and Z(cis)-10-hydroxynortriptyline. These compounds are ...