The purpose of our study is to develop a controlled Naproxen releasing system for anti-inflammatory, analgesic treatments. Interpenetrating polymer network (IPN) type hydrogels were obtained by using natural polymers alginate and gelatin. prepared combining Alginate Gelatin in the presence Glutaraldehyde as crosslinker Montmorillonite (MMT) clay was used nano-dimensioned layered dopant. charact...

Development of the technique for constructing an internal perfusable vascular network is a challenging issue in fabrication of dense three-dimensional tissues in vitro. Here, we report a method for realizing it. We assembled small tissue (about 200 μm in diameter)-enclosing hydrogel microcapsules and a single hydrogel fiber, both covered with human vascular endothelial cells in a collagen gel. ...

In-situ forming polymeric formulations drug delivery systems is in solution form before administration in the body, but once administered, undergoes gelatin in-situ to form a gel. The formulation of gel depends upon factors like temperature modulation, pH changes, presence of ions and ultra-violet irradiation, from which drug gets released in sustained and controlled manner. The object of this ...

The water-soluble biopolymers, gelatin and sodium alginate, were investigated as potential alternative binders for use in lithium-ion battery anodes. polymers modified using a deep eutectic solvent (DES) made from choline chloride glycerol. It was found that the addition of DES resulted greater plasticity adhesion with respect to unmodified also current commonly used PVDF or CMC/SBR binders. Bo...

The aim of this study was to find a proper method for improvement of ischemic condition in the rat hind limb and also to observe the efficacy of cell engraftment with alginate/gelatin three-dimensional scaffolds. Eighteen male Wistar rats weighing 200 to 250 g were randomly divided into three groups (n = 6) including a) ischemia group; in which femoral artery was removed after ligation at the d...

Hydrogels comprised of alginate and gelatin are potential biomaterials for extrusion-based bioprinting. However, existing polymeric inks inadequate in printability, shape fidelity mechanical properties that desire to produce scaffold using 3D Here, a novel printable hydrogel-based ink solution gelatin-alginate (GA) reinforced by boron nitride nanotubes (BNNTs) was developed bioprinting tissue e...

Film-forming solutions based on four types of biopolymers were prepared and their rheological properties determined. High methylated apple pectin sodium alginate used at the concentrations 1%, 1.5%, 2%, whereas soy protein isolate pork gelatin obtained 4%, 8%, 12%. The parameters determining production appropriate type packaging film or edible coating are setting time substrate, regardless its ...

Myocardial infarction (MI), caused by the occlusion of the left ventricular coronary artery, leads to the loss of cardiomyocytes and, potentially, heart failure. Cardiomyocytes in adult mammals proliferate at an extremely low rate and thus, a major challenge in MI treatment is supplementing exogenous cells and keeping them viable in MI areas. To address this challenge, injecting hydrogels encap...

The objective of the present study was to develop and evaluate a sustained release Gelatin-sodium alginate biodegradable polymeric implant containing Simvastatin, an inhibitor of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase, which reduces low-density-lipoprotein (LDL) cholesterol. Implants were prepared by heating and congealing method with different polymer ratios and excipients. I...