Background Prussian blue (PB, ferric hexacyanoferrate) is approved by US-FDA for internal decorporation of Cesium-137 (137Cs) and Thallium-201 (201Tl). Aim Since PB is a costly drug, pH-dependent oral delivery system of PB was developed using calcium alginate matrix system. Methods Alginate (Alg) beads containing PB were optimized by gelation of sodium alginate with calcium ions and effect ...

The alginate-graphene oxide mixture has been extensively studied due to its capacity adsorb heavy metals, presenting higher structural and thermal stability than alginate. These properties adsorption would be related the presence of functional groups present in hydrocarbon chain alginate graphene oxide, such as carboxylic, hydroxyl, ketone, epoxy groups; study, interaction transition cations th...

conclusions algino-pectinate mucoadhesive formulations exhibited promising properties of a sustained release form for piroxicam and provided distinct tissue protection in stomach. objective the purpose of this research was to decrease gastric side effects of piroxicam by formulating microspheres of alginate and algino-pectinate beads of the drug. materials and methods ionotropic gelation was us...

A simple strategy is provided to construct novel supramolecular hydrogels with both self-healing and shape memory properties. Starting from achieving self-healable hydrogel based on the dynamic interactions of phenylboronic acid modified sodium alginate (Alg-PBA) and poly(vinyl alcohol) (PVA), further formation of a complex of alginate with Ca(2+) renders this hydrogel with the capability of sh...

Purpose. The antitumor activity of a novel alginate (ALG) polymer-based particle that contained paclitaxel (PTX) was evaluated using human primary breast cancer cells. Materials and Methods. PTX was combined with ALG in a nanoparticle as a drug delivery system designed to improve breast cancer tumor cell killing. PTX-ALG nanoparticles were first synthesized by nanoemulsification polymer cross-l...

In this study, 2-[(Acryloyloxy)ethyl]trimethylammonium chloride was graft polymerized onto chitosan (CS) to form quaternary ammonium CS (QAC) by using ammonium persulfate as a redox initiator. Alginate (ALG) microspheres loaded with a water-soluble macromolecular model drug, blue dextran (BD), were obtained by corporation of coaxial gas-flow method and ionic gelation process. CS and QAC were th...

Extracellular polymers can facilitate the non-specific attachment of bacteria to surfaces and hold together developing biofilms. This study was undertaken to qualitatively and quantitatively compare the architecture of biofilms produced by Pseudomonas aeruginosa strain PAO1 and its alginate-overproducing (mucA22) and alginate-defective (algD) variants in order to discern the role of alginate in...

BACKGROUND Targeted drug delivery to colon would ensure direct treatment at the disease site, decrease in dose administration and reduction side effects improved drug utilization. OBJECTIVE The purpose of this research was to decrease gastric side effects of piroxicam by formulating microspheres of alginate and algino-pectinate beads of the drug. MATERIALS AND METHODS Ionotropic gelation wa...

Abstract Alginate–zinc oxide (Alg–ZnO) biocomposite was synthesized and tested as a chromium ions Cr(VI) adsorbent for environmental applications. Alg–ZnO prepared by the interaction between sodium alginate biopolymer zinc nanoparticles (ZnO–NPs), modified wet chemical method. The solid adsorption characteristics of were characterized Fourier transform infrared spectroscopy (FTIR), X-ray diffra...

Objective(s): It is proposed that particulate antigens could better interact with the antigen presenting cells (APCs). A fast, simple and scalable process for preparation of polymeric nanoparticles (NPs) is coating of charged antigenic particles, like viruses, with oppositely charged polymers. A second coating with a charged polymer could increase the stability and modify the immunomodulatory p...