PURPOSE To identify sexual function improvement associated with alfuzosin (10 mg daily for 2 years). MATERIALS AND METHODS We enrolled 30 men with lower urinary tract symptom (LUTS) who visited Gyeongsang National University Hospital between 2010 and 2012. At first visit, urinalysis, prostate specific antigen, transrectal ultrasound, and uroflowmetry were performed. The nternational Prostate ...

PURPOSE In this study, we examined the difference in the treatment efficacy depending on the sympathetic activity in men with lower urinary tract symptoms (LUTS). METHODS In the current single-center, retrospective study, we evaluated a total of 66 male patients aged 40-70 years of age, presenting with LUTS, whose International Prostate Symptom Score (IPSS) exceeded 8 points. They had a past ...

PURPOSE In this study, we compared the treatment outcomes for an α-blocker between 2 groups of men, one with high sympathetic activity (HSA) and another with low sympathetic activity (LSA) or normal sympathetic activity. METHODS A total of 159 men (≥50 years of age) with lower urinary tract symptoms resulting from benign prostatic hyperplasia were analyzed. We assigned patients to groups acco...

The effects of different alpha-1 adrenoceptor blockers on the urethra and the cardiovascular system were evaluated using an in vivo isovolumetric intra-urethral pressure model in New Zealand white rabbits. The urethra of anesthetized male rabbits was cannulated through the bladder and secured at the vesico-urethral junction. The distal side of urethra under the pubic bone was also closed to all...

Two simple and sensitive methods A and B for the spectrophotometric determination of Alfuzosin hydrochloride have been described. These methods are based on the formation of purple color and redviolet colored chromogens obtained when the drug was diazotized with nitrous acid followed by coupling with Phloroglucinol and Resorcinol, exhibiting λmax at 520 and 600 nm respectively. These methods ob...

A simple, precise and low cost conductometric method for the determination of alfuzosin hydrochloride and fexofenadine hydrochloride in pure form and pharmaceutical formulations using sodium tetraphenylborate has been described. The method is based on the formation of ion association complex of cations coming from the cited drugs with tetraphenylborate anions and the conductance of the solution...

Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor, which inhibits the activity of both isoforms of COX (1 and 2). Also, flurbiprofen is one of the most potent non-steroidal anti-inflammatory agent (NSAIDs) in terms of prostaglandin inhibitory activity via reversible inhibition of COX, the enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 ...

Studies were identified on internet by searching on address: http://www.ncbi.nlm.nih.gov/pubmed/ with criteria that studies should be placebo-controlled and randomized in trials of alpha-blockers in chronic category III prostatitis evaluated by symptom-score NIH-CPSI. From 13 clinical studies three were excluded because of not using NIH-CPSI, three were in Chinese language and two were congress...

      Extended release formulation of alfuzosin, an a-antagonist used for prostatic hypertrophy, is available in market. It is convenient for older patients to take only one tablet a day. Marketed alfuzosin formulation is three layered geomatrix tablet that requires special facilities, high cost, more time and complex operation than normal direct compression formulation. Therefore, a less compl...