Behavioral, anatomic, and electrophysiologic studies indicate that the nondecussated optic system is functionally incompetent and anatomically disorganized in albino animals. The number of nondecussated optic nerve fibers from the retina to the lateral geniculate nuclei, pretectal nuclei, and superior colliculi is significantly reduced in albino mammals, and the laminae of the dorsal lateral ge...

Reduction of the melanin precursor DOPA associated with albinism leads to spatiotemporal disturbances in retinal neurogenesis and thus seems to be responsible for numerous neuronal alterations found in albino retinae. To investigate whether these cellular alterations are reflected in retinal neurotransmitter concentrations we compared the levels of GABA and glutamate in the retina of adult pigm...

Background/aims: Past studies have explored some of the associations between particular motor and sensory characteristics and specific categories of non-neurological infantile nystagmus. The purpose of this case study is to extend this body of work significantly by describing the trends and associations found in a database of 224 subjects who have undergone extensive clinical and psychophysical...

Investigations were undertaken to determine which particular components of the flash visual-evoked cortical potential (VECP) lateralize on monocular stimulation in human albinos. Our results demonstrate that only the major positive component shows clear lateralization. Statistical analysis revealed that the latency lateralization was significant (P less than 0.001) while the amplitude lateraliz...

BACKGROUND The absence or deficiency of melanin as in albinos, has detrimental effects on retinal development that include aberrant axonal projections from eye to brain and impaired vision. In pigmented retinal pigment epithelium (RPE), dihydroxyphenalanine (L-Dopa), an intermediate in the synthetic path for melanin, has been hypothesized to regulate the tempo of neurogenesis. The time course o...

Objetivo: trazer conhecimentos sobre a hereditariedade do albinismo em famílias da Bahia, estado com estimativa de taxa elevada característica. Métodos: pesquisa seccional descritiva por amostragem conveniência, consulta às fichas atendimento programa Genética e Sociedade (Instituto Biologia- UFBA) ao banco dados Associação Pessoas Albinismo Bahia (APALBA). Resultados: no total 457 albinos, ver...