Abstract Radix puerariae has become the most commonly used medicine for diabetic nephropathy (DN). However, mechanism of in treatment DN is not completely clear. This study to determine active ingredients, targets, and signaling pathways using network pharmacology analysis animal experiments confirm its possible action. A total 12 potential effective components 10 key therapeutic targets were o...

Obesity and exercise lead to structural changes in heart such as cardiac hypertrophy. The underlying signaling pathways vary according the source of overload, be it physiological (exercise) or pathologic (obesity). pathway relies more on PI3K-Akt while involves calcineurin-Nuclear factor activated T-cells activation fibrosis accumulation. Independently, polyphenols have demonstrated prevent The...

Background: Triple-negative breast cancer (TNBC) is a great threat to global women's health due its high metastatic potential. Epithelial-to-mesenchymal transition (EMT) considered as key event in the process of metastasis. So pharmacological targeting EMT might be promising strategy improving therapeutic efficacy TNBC. Here, we investigated effect shikonin exerting on and consequently metastas...

Introduction: The mechanism of putative cytotoxicity of 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidone (rolipram), a specific phosphodiesterase-4 (PDE4) inhibitor, on glioblastoma multiforme (GBM) is almost unknown. This study aimed to investigate the role of protein kinase B (Akt) pathway in the cytotoxic effect of rolipram on human GBM U87 MG cell line and tumor-initiating cells (TICs) ...

A Retraction of the Original research article “Astragali Radix Isoflavones Synergistically Alleviate Cerebral Ischemia and Reperfusion Injury Via Activating Estrogen Receptor-PI3K-Akt Signaling Pathway”Gu Y, Chen X, Fu S, Liu W, Wang Q, K-J Shen J (2021) Astragali Receptor□PI3K-Akt Pathway. Front. Pharmacol. 12:533028. doi: 10.3389/fphar.2021.533028"Following publication, concerns were raised r...

Few studies have focused on ?-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) in tumor progression. We investigated the expression and importance of GABARAP breast cancer. analyzed its relationship with clinicopathological features prognosis (TCGA). To explain role potential mechanism regulating development, we performed acquisition loss function experiments using cell li...

Purpose: To determine the role and mechanisms of Krüppel-like transcription factor 8 (KLF8) in acute myeloid leukemia (AML).Methods: The transcriptional translational levels KLF8 AML cell lines were determined by quantitative real time-polymerase chain reaction (qRT-PCR) western blotting. Two RNAs targeting transfected into KG-1 HL-60 cells. growth apoptosis cells using CCK-8, 5-ethynyl-2-deoxy...

Purpose: To investigate the effect of forkhead box N3 (FOXN3) protein on doxorubicin (DOX) resistance urothelial carcinoma (BLCA).
 Methods: Bioinformatics prediction and immunoblotting were used to evaluate FOXN3 expression in BLCA tissues cells. The overexpression was achieved by cell transfection. effects DOX apoptosis determined immunoblotting, assay, flow cytometry, while applied SIRT...

Purpose: To investigate the influence of elemene on growth and apoptotic changes in bladder cancer cells, involvement phosphatase tensin homologous protein (PTEN)-serine/threonine kinase (Akt) signal pathway process.
 Methods: Human cell line SV-HUC-1 human T24 were randomly assigned to blank control group groups. Protein expression levels apoptosis-related factors (Bcl-2, Bax, caspase-3] ...